Analysis of the Mechanism of <i>Salvia miltiorrhiza</i> in the Treatment of Pancreatic Cancer Based on Network Pharmacology

Xueling Tan; Jiajun Chen; Yuting Bai; Xin Chen

doi:doi:10.11648/j.bs.20230903.11

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Analysis of the Mechanism of Salvia miltiorrhiza in the Treatment of Pancreatic Cancer Based on Network Pharmacology

Xueling Tan, Jiajun Chen, Yuting Bai, Xin Chen

Published in Biomedical Sciences (Volume 9, Issue 3)

Received: 5 July 2023 Accepted: 19 July 2023 Published: 27 July 2023

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Abstract

Objective: To explore the potential molecular mechanism of Salvia miltiorrhiza in the treatment of pancreatic cancer using network pharmacology. Methods: The active components and their corresponding core targets in Salvia miltiorrhiza were screened by TCMSP database, and the corresponding gene Symbol of core targets was obtained by using Uniprot database. The gene targets for pancreatic cancer were searched from Gene Cards, OMIM, TTD and DrugBank databases. The potential targets of Salvia miltiorrhiza were matched with pancreatic cancer gene targets using Venn diagram, and the active components-targets network of Salvia miltiorrhiza and the active components-targets network of Salvia miltiorrhiza were mapped using Cytoscape software. The DAVID database was used to perform Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis to predict the potential mechanisms of targets. Results: A total of 65 active components of Salvia miltiorrhiza were screened, corresponding to 118 targets. A total of 2167 pancreatic cancer disease targets were screened, and 75 Salvia miltiorrhiza-pancreatic cancer crossover targets were obtained. Six core targets were obtained by PPI network analysis. Luteolin, tanshinone, quercetin and dihydrodanshinolide were the main active components, and ESR1, JUN, CDKN1A, MAPK14, MYC and TP53 were the main core targets. The results of GO analysis showed that the cellular components where the 75 targets of Salvia miltiorrhiza for pancreatic cancer therapy function are mainly the nucleus, membrane rafts, spindle, and membrane microdomains. The biological processes are mainly in response to radiation, response to xennobiotic stimulus, gland development, and so on. Molecular functions include DNA binding transcription factors, specific RNA polymerase II binding transcription factors, and regulation of kinase activity. 75 targets of Salvia miltiorrhiza for pancreatic cancer treatment are mainly through PI3K/Akt signaling pathway, cancer signaling pathway, pancreatic cancer signaling pathway, HIF-1 signaling pathway and other pathways to regulate tumor immune response, induce apoptosis, promote cell cycle arrest, and tumor metastasis, promote cell cycle arrest and tumor metastasis. Conclusions: This study reveals that Salvia miltiorrhiza may regulate multiple signaling pathways through multiple targets, thus acting as a therapeutic agent for pancreatic cancer, which also provides theoretical support for the clinical discovery of alternative drugs for pancreatic cancer treatment.

Published in	Biomedical Sciences (Volume 9, Issue 3)
DOI	10.11648/j.bs.20230903.11
Page(s)	53-59
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Network Pharmacology, Pancreatic Cancer, Mechanism, Salvia miltiorrhiza

References

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APA Style

Xueling Tan, Jiajun Chen, Yuting Bai, Xin Chen. (2023). Analysis of the Mechanism of Salvia miltiorrhiza in the Treatment of Pancreatic Cancer Based on Network Pharmacology. Biomedical Sciences, 9(3), 53-59. https://doi.org/10.11648/j.bs.20230903.11

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ACS Style

Xueling Tan; Jiajun Chen; Yuting Bai; Xin Chen. Analysis of the Mechanism of Salvia miltiorrhiza in the Treatment of Pancreatic Cancer Based on Network Pharmacology. Biomed. Sci. 2023, 9(3), 53-59. doi: 10.11648/j.bs.20230903.11

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AMA Style

Xueling Tan, Jiajun Chen, Yuting Bai, Xin Chen. Analysis of the Mechanism of Salvia miltiorrhiza in the Treatment of Pancreatic Cancer Based on Network Pharmacology. Biomed Sci. 2023;9(3):53-59. doi: 10.11648/j.bs.20230903.11

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@article{10.11648/j.bs.20230903.11,
  author = {Xueling Tan and Jiajun Chen and Yuting Bai and Xin Chen},
  title = {Analysis of the Mechanism of Salvia miltiorrhiza in the Treatment of Pancreatic Cancer Based on Network Pharmacology},
  journal = {Biomedical Sciences},
  volume = {9},
  number = {3},
  pages = {53-59},
  doi = {10.11648/j.bs.20230903.11},
  url = {https://doi.org/10.11648/j.bs.20230903.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230903.11},
  abstract = {Objective: To explore the potential molecular mechanism of Salvia miltiorrhiza in the treatment of pancreatic cancer using network pharmacology. Methods: The active components and their corresponding core targets in Salvia miltiorrhiza were screened by TCMSP database, and the corresponding gene Symbol of core targets was obtained by using Uniprot database. The gene targets for pancreatic cancer were searched from Gene Cards, OMIM, TTD and DrugBank databases. The potential targets of Salvia miltiorrhiza were matched with pancreatic cancer gene targets using Venn diagram, and the active components-targets network of Salvia miltiorrhiza and the active components-targets network of Salvia miltiorrhiza were mapped using Cytoscape software. The DAVID database was used to perform Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis to predict the potential mechanisms of targets. Results: A total of 65 active components of Salvia miltiorrhiza were screened, corresponding to 118 targets. A total of 2167 pancreatic cancer disease targets were screened, and 75 Salvia miltiorrhiza-pancreatic cancer crossover targets were obtained. Six core targets were obtained by PPI network analysis. Luteolin, tanshinone, quercetin and dihydrodanshinolide were the main active components, and ESR1, JUN, CDKN1A, MAPK14, MYC and TP53 were the main core targets. The results of GO analysis showed that the cellular components where the 75 targets of Salvia miltiorrhiza for pancreatic cancer therapy function are mainly the nucleus, membrane rafts, spindle, and membrane microdomains. The biological processes are mainly in response to radiation, response to xennobiotic stimulus, gland development, and so on. Molecular functions include DNA binding transcription factors, specific RNA polymerase II binding transcription factors, and regulation of kinase activity. 75 targets of Salvia miltiorrhiza for pancreatic cancer treatment are mainly through PI3K/Akt signaling pathway, cancer signaling pathway, pancreatic cancer signaling pathway, HIF-1 signaling pathway and other pathways to regulate tumor immune response, induce apoptosis, promote cell cycle arrest, and tumor metastasis, promote cell cycle arrest and tumor metastasis. Conclusions: This study reveals that Salvia miltiorrhiza may regulate multiple signaling pathways through multiple targets, thus acting as a therapeutic agent for pancreatic cancer, which also provides theoretical support for the clinical discovery of alternative drugs for pancreatic cancer treatment.},
 year = {2023}
}

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TY  - JOUR
T1  - Analysis of the Mechanism of Salvia miltiorrhiza in the Treatment of Pancreatic Cancer Based on Network Pharmacology
AU  - Xueling Tan
AU  - Jiajun Chen
AU  - Yuting Bai
AU  - Xin Chen
Y1  - 2023/07/27
PY  - 2023
N1  - https://doi.org/10.11648/j.bs.20230903.11
DO  - 10.11648/j.bs.20230903.11
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 53
EP  - 59
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20230903.11
AB  - Objective: To explore the potential molecular mechanism of Salvia miltiorrhiza in the treatment of pancreatic cancer using network pharmacology. Methods: The active components and their corresponding core targets in Salvia miltiorrhiza were screened by TCMSP database, and the corresponding gene Symbol of core targets was obtained by using Uniprot database. The gene targets for pancreatic cancer were searched from Gene Cards, OMIM, TTD and DrugBank databases. The potential targets of Salvia miltiorrhiza were matched with pancreatic cancer gene targets using Venn diagram, and the active components-targets network of Salvia miltiorrhiza and the active components-targets network of Salvia miltiorrhiza were mapped using Cytoscape software. The DAVID database was used to perform Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis to predict the potential mechanisms of targets. Results: A total of 65 active components of Salvia miltiorrhiza were screened, corresponding to 118 targets. A total of 2167 pancreatic cancer disease targets were screened, and 75 Salvia miltiorrhiza-pancreatic cancer crossover targets were obtained. Six core targets were obtained by PPI network analysis. Luteolin, tanshinone, quercetin and dihydrodanshinolide were the main active components, and ESR1, JUN, CDKN1A, MAPK14, MYC and TP53 were the main core targets. The results of GO analysis showed that the cellular components where the 75 targets of Salvia miltiorrhiza for pancreatic cancer therapy function are mainly the nucleus, membrane rafts, spindle, and membrane microdomains. The biological processes are mainly in response to radiation, response to xennobiotic stimulus, gland development, and so on. Molecular functions include DNA binding transcription factors, specific RNA polymerase II binding transcription factors, and regulation of kinase activity. 75 targets of Salvia miltiorrhiza for pancreatic cancer treatment are mainly through PI3K/Akt signaling pathway, cancer signaling pathway, pancreatic cancer signaling pathway, HIF-1 signaling pathway and other pathways to regulate tumor immune response, induce apoptosis, promote cell cycle arrest, and tumor metastasis, promote cell cycle arrest and tumor metastasis. Conclusions: This study reveals that Salvia miltiorrhiza may regulate multiple signaling pathways through multiple targets, thus acting as a therapeutic agent for pancreatic cancer, which also provides theoretical support for the clinical discovery of alternative drugs for pancreatic cancer treatment.
VL  - 9
IS  - 3
ER  -

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Author Information

Xueling Tan

Department of Clinical Laboratory, Nanchong Central Hospital Affiliated to North Sichuan Medical College, Nanchong, China
Jiajun Chen

Department of Clinical Laboratory, Gaoping District People’s Hospital of Nanchong, Nanchong, China
Yuting Bai

Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
Xin Chen

Department of Rehabilitation Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, China

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Plain Text BibTeX RIS

APA Style

Xueling Tan, Jiajun Chen, Yuting Bai, Xin Chen. (2023). Analysis of the Mechanism of Salvia miltiorrhiza in the Treatment of Pancreatic Cancer Based on Network Pharmacology. Biomedical Sciences, 9(3), 53-59. https://doi.org/10.11648/j.bs.20230903.11

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ACS Style

Xueling Tan; Jiajun Chen; Yuting Bai; Xin Chen. Analysis of the Mechanism of Salvia miltiorrhiza in the Treatment of Pancreatic Cancer Based on Network Pharmacology. Biomed. Sci. 2023, 9(3), 53-59. doi: 10.11648/j.bs.20230903.11

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AMA Style

Xueling Tan, Jiajun Chen, Yuting Bai, Xin Chen. Analysis of the Mechanism of Salvia miltiorrhiza in the Treatment of Pancreatic Cancer Based on Network Pharmacology. Biomed Sci. 2023;9(3):53-59. doi: 10.11648/j.bs.20230903.11

Copy | Download

@article{10.11648/j.bs.20230903.11,
  author = {Xueling Tan and Jiajun Chen and Yuting Bai and Xin Chen},
  title = {Analysis of the Mechanism of Salvia miltiorrhiza in the Treatment of Pancreatic Cancer Based on Network Pharmacology},
  journal = {Biomedical Sciences},
  volume = {9},
  number = {3},
  pages = {53-59},
  doi = {10.11648/j.bs.20230903.11},
  url = {https://doi.org/10.11648/j.bs.20230903.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230903.11},
  abstract = {Objective: To explore the potential molecular mechanism of Salvia miltiorrhiza in the treatment of pancreatic cancer using network pharmacology. Methods: The active components and their corresponding core targets in Salvia miltiorrhiza were screened by TCMSP database, and the corresponding gene Symbol of core targets was obtained by using Uniprot database. The gene targets for pancreatic cancer were searched from Gene Cards, OMIM, TTD and DrugBank databases. The potential targets of Salvia miltiorrhiza were matched with pancreatic cancer gene targets using Venn diagram, and the active components-targets network of Salvia miltiorrhiza and the active components-targets network of Salvia miltiorrhiza were mapped using Cytoscape software. The DAVID database was used to perform Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis to predict the potential mechanisms of targets. Results: A total of 65 active components of Salvia miltiorrhiza were screened, corresponding to 118 targets. A total of 2167 pancreatic cancer disease targets were screened, and 75 Salvia miltiorrhiza-pancreatic cancer crossover targets were obtained. Six core targets were obtained by PPI network analysis. Luteolin, tanshinone, quercetin and dihydrodanshinolide were the main active components, and ESR1, JUN, CDKN1A, MAPK14, MYC and TP53 were the main core targets. The results of GO analysis showed that the cellular components where the 75 targets of Salvia miltiorrhiza for pancreatic cancer therapy function are mainly the nucleus, membrane rafts, spindle, and membrane microdomains. The biological processes are mainly in response to radiation, response to xennobiotic stimulus, gland development, and so on. Molecular functions include DNA binding transcription factors, specific RNA polymerase II binding transcription factors, and regulation of kinase activity. 75 targets of Salvia miltiorrhiza for pancreatic cancer treatment are mainly through PI3K/Akt signaling pathway, cancer signaling pathway, pancreatic cancer signaling pathway, HIF-1 signaling pathway and other pathways to regulate tumor immune response, induce apoptosis, promote cell cycle arrest, and tumor metastasis, promote cell cycle arrest and tumor metastasis. Conclusions: This study reveals that Salvia miltiorrhiza may regulate multiple signaling pathways through multiple targets, thus acting as a therapeutic agent for pancreatic cancer, which also provides theoretical support for the clinical discovery of alternative drugs for pancreatic cancer treatment.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Analysis of the Mechanism of Salvia miltiorrhiza in the Treatment of Pancreatic Cancer Based on Network Pharmacology
AU  - Xueling Tan
AU  - Jiajun Chen
AU  - Yuting Bai
AU  - Xin Chen
Y1  - 2023/07/27
PY  - 2023
N1  - https://doi.org/10.11648/j.bs.20230903.11
DO  - 10.11648/j.bs.20230903.11
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 53
EP  - 59
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20230903.11
AB  - Objective: To explore the potential molecular mechanism of Salvia miltiorrhiza in the treatment of pancreatic cancer using network pharmacology. Methods: The active components and their corresponding core targets in Salvia miltiorrhiza were screened by TCMSP database, and the corresponding gene Symbol of core targets was obtained by using Uniprot database. The gene targets for pancreatic cancer were searched from Gene Cards, OMIM, TTD and DrugBank databases. The potential targets of Salvia miltiorrhiza were matched with pancreatic cancer gene targets using Venn diagram, and the active components-targets network of Salvia miltiorrhiza and the active components-targets network of Salvia miltiorrhiza were mapped using Cytoscape software. The DAVID database was used to perform Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis to predict the potential mechanisms of targets. Results: A total of 65 active components of Salvia miltiorrhiza were screened, corresponding to 118 targets. A total of 2167 pancreatic cancer disease targets were screened, and 75 Salvia miltiorrhiza-pancreatic cancer crossover targets were obtained. Six core targets were obtained by PPI network analysis. Luteolin, tanshinone, quercetin and dihydrodanshinolide were the main active components, and ESR1, JUN, CDKN1A, MAPK14, MYC and TP53 were the main core targets. The results of GO analysis showed that the cellular components where the 75 targets of Salvia miltiorrhiza for pancreatic cancer therapy function are mainly the nucleus, membrane rafts, spindle, and membrane microdomains. The biological processes are mainly in response to radiation, response to xennobiotic stimulus, gland development, and so on. Molecular functions include DNA binding transcription factors, specific RNA polymerase II binding transcription factors, and regulation of kinase activity. 75 targets of Salvia miltiorrhiza for pancreatic cancer treatment are mainly through PI3K/Akt signaling pathway, cancer signaling pathway, pancreatic cancer signaling pathway, HIF-1 signaling pathway and other pathways to regulate tumor immune response, induce apoptosis, promote cell cycle arrest, and tumor metastasis, promote cell cycle arrest and tumor metastasis. Conclusions: This study reveals that Salvia miltiorrhiza may regulate multiple signaling pathways through multiple targets, thus acting as a therapeutic agent for pancreatic cancer, which also provides theoretical support for the clinical discovery of alternative drugs for pancreatic cancer treatment.
VL  - 9
IS  - 3
ER  -

Copy | Download