Skin acts as a barrier and is an important part of body immune system. External physical, biochemical and other stimuli might cause skin inflammation. Drugs and cosmetics have been developed for skin inflammation treatment. At present, the tests of skin inflammation are mainly conducted on animal and 2D cell models. The former might bring problems such as ethics and authenticity, while the latter cannot fully represent the complex micro-environment of the human body. Microfluidic based Organ-on- a- chips technology provides a new method for drug and cosmetic ingredient screening. Skin-on-a-chip (SOC) has been designed for constructing in vitro skin models. In this paper, a SOC was developed to culture skin-like models in vitro. We tested the differentiation of SOC cultured skin model, and the results showed that its stratum corneum was well differentiated. It indicates that the skin tissue cultured by the SOC bears some similarities to human skin, which can be used for subsequent drug testing. We tested the anti-inflammatory effect of gentiopicroside and compared with dexamethasone. The results showed that 5μg/ml~50μg/ml of gentiopicroside had similar anti-inflammatory effect to 1μM of dexamethasone.
| Published in | American Journal of Bioscience and Bioengineering (Volume 11, Issue 1) |
| DOI | 10.11648/j.bio.20231101.12 |
| Page(s) | 7-13 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Skin, Microfluidic Technology, Anti-inflammatory
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APA Style
Zijia Liu, Yidong Tu, Tianbi Duan, Zhi Lv, Ruixue Yin, et al. (2023). Rapid Evaluation of Anti-inflammatory Effect of Geniopicroside. American Journal of Bioscience and Bioengineering, 11(1), 7-13. https://doi.org/10.11648/j.bio.20231101.12
ACS Style
Zijia Liu; Yidong Tu; Tianbi Duan; Zhi Lv; Ruixue Yin, et al. Rapid Evaluation of Anti-inflammatory Effect of Geniopicroside. Am. J. BioSci. Bioeng. 2023, 11(1), 7-13. doi: 10.11648/j.bio.20231101.12
AMA Style
Zijia Liu, Yidong Tu, Tianbi Duan, Zhi Lv, Ruixue Yin, et al. Rapid Evaluation of Anti-inflammatory Effect of Geniopicroside. Am J BioSci Bioeng. 2023;11(1):7-13. doi: 10.11648/j.bio.20231101.12
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Download@article{10.11648/j.bio.20231101.12,
author = {Zijia Liu and Yidong Tu and Tianbi Duan and Zhi Lv and Ruixue Yin and Hongbo Zhang},
title = {Rapid Evaluation of Anti-inflammatory Effect of Geniopicroside},
journal = {American Journal of Bioscience and Bioengineering},
volume = {11},
number = {1},
pages = {7-13},
doi = {10.11648/j.bio.20231101.12},
url = {https://doi.org/10.11648/j.bio.20231101.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20231101.12},
abstract = {Skin acts as a barrier and is an important part of body immune system. External physical, biochemical and other stimuli might cause skin inflammation. Drugs and cosmetics have been developed for skin inflammation treatment. At present, the tests of skin inflammation are mainly conducted on animal and 2D cell models. The former might bring problems such as ethics and authenticity, while the latter cannot fully represent the complex micro-environment of the human body. Microfluidic based Organ-on- a- chips technology provides a new method for drug and cosmetic ingredient screening. Skin-on-a-chip (SOC) has been designed for constructing in vitro skin models. In this paper, a SOC was developed to culture skin-like models in vitro. We tested the differentiation of SOC cultured skin model, and the results showed that its stratum corneum was well differentiated. It indicates that the skin tissue cultured by the SOC bears some similarities to human skin, which can be used for subsequent drug testing. We tested the anti-inflammatory effect of gentiopicroside and compared with dexamethasone. The results showed that 5μg/ml~50μg/ml of gentiopicroside had similar anti-inflammatory effect to 1μM of dexamethasone.},
year = {2023}
}
TY - JOUR T1 - Rapid Evaluation of Anti-inflammatory Effect of Geniopicroside AU - Zijia Liu AU - Yidong Tu AU - Tianbi Duan AU - Zhi Lv AU - Ruixue Yin AU - Hongbo Zhang Y1 - 2023/05/29 PY - 2023 N1 - https://doi.org/10.11648/j.bio.20231101.12 DO - 10.11648/j.bio.20231101.12 T2 - American Journal of Bioscience and Bioengineering JF - American Journal of Bioscience and Bioengineering JO - American Journal of Bioscience and Bioengineering SP - 7 EP - 13 PB - Science Publishing Group SN - 2328-5893 UR - https://doi.org/10.11648/j.bio.20231101.12 AB - Skin acts as a barrier and is an important part of body immune system. External physical, biochemical and other stimuli might cause skin inflammation. Drugs and cosmetics have been developed for skin inflammation treatment. At present, the tests of skin inflammation are mainly conducted on animal and 2D cell models. The former might bring problems such as ethics and authenticity, while the latter cannot fully represent the complex micro-environment of the human body. Microfluidic based Organ-on- a- chips technology provides a new method for drug and cosmetic ingredient screening. Skin-on-a-chip (SOC) has been designed for constructing in vitro skin models. In this paper, a SOC was developed to culture skin-like models in vitro. We tested the differentiation of SOC cultured skin model, and the results showed that its stratum corneum was well differentiated. It indicates that the skin tissue cultured by the SOC bears some similarities to human skin, which can be used for subsequent drug testing. We tested the anti-inflammatory effect of gentiopicroside and compared with dexamethasone. The results showed that 5μg/ml~50μg/ml of gentiopicroside had similar anti-inflammatory effect to 1μM of dexamethasone. VL - 11 IS - 1 ER -
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