Modified Atkins Diet Delayed the Onset of Epileptogenesis, Improved Motor Coordination and Enhanced Learning Memory in Mice

Maryam Adenike Salaudeen; Mohammed Garba Magaji; Abdulkadir Umar Zezi

doi:doi:10.11648/j.bio.20231101.11

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Modified Atkins Diet Delayed the Onset of Epileptogenesis, Improved Motor Coordination and Enhanced Learning Memory in Mice

Maryam Adenike Salaudeen, Mohammed Garba Magaji, Abdulkadir Umar Zezi

Published in American Journal of Bioscience and Bioengineering (Volume 11, Issue 1)

Received: 29 December 2022 Accepted: 25 January 2023 Published: 4 March 2023

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Abstract

Modified Atkins diet is a high fat, moderate protein and carbohydrate diet that has long been used to manage intractable epilepsy in developed countries. However, the use of this diet for same condition is uncommon in most low- and middle-income countries including Nigeria. In a previous research, we formulated modified Atkins diet using cheap and locally-available food materials in Nigeria. This research is thus, aimed at evaluating the effect of the formulated modified Atkins diet on seizure plasticity using the PTZ-induced kindling model of seizure. We also investigated the effect of sub-chronic use (60 days) of the diet on motor coordination using positional sense test and on visual-spatial reference and learning memory using Morris-water maze. The result revealed that the formulated modified Atkins diet significantly (p<0.05) increased seizure plasticity by reducing the severity of seizure as well as delaying the onset of tonic-clonic seizure and death. The diet also enhanced motor coordination, and improved learning memory, but not reference memory in mice. We therefore concluded that the formulated modified Atkins diet may be of benefit in the management of intractable/treatment-resistant epilepsy, especially in patients who are already suffering from amnesia and/or postural instability since the diet was able to offer protection against seizure-induced memory loss and motor-incoordination in mice.

Published in	American Journal of Bioscience and Bioengineering (Volume 11, Issue 1)
DOI	10.11648/j.bio.20231101.11
Page(s)	1-6
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Nigerian-Made, Modified Atkins Diet, PTZ-Induced Kindling, Epileptogenesis, Epilepsy

References

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[3]	Nunes VD, Sawyer L, Neilson J, Sarri G, and Cross JH. “Diagnosis and management of the epilepsies in adults and children: summary of updated NICE guidance BMJ, 2012: 344, 281.
[4]	Meira, I. D. A., Romão, T. T., Prado, H. J. Pd., Conceição, aP. Od., Krüger, L. T., and Pires M. E. P. Ketogenic Diet and Epilepsy: What We Know So Far. Frontiers in Neuroscience, 2019, 13.
[5]	Kossoff, E. H., McGrogan, J. R., Bluml, R. M., Pillas, D. J., Rubenstein, J. E, and Vining, E. P. A Modified Atkins Diet Is Effective for the Treatment of Intractable Pediatric Epilepsy. Epilepsia, 2006: 47 (2), 421-424.
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[7]	Sudha KK, Elizabeth GN, Carol SC and Kossoff EH. Dietary therapies for epilepsy: Future research. PMC, 2018: 22 (1), 17–22. doi: 10.1016/j.yebeh.2011.02.018.
[8]	Salaudeen MA, Magaji MG, Zezi AU. Paradoxical Seizure Effect of Modified Atkins Diet in Mice. Nig J Pharm Scis, 2020: 19 (1): 121-125.
[9]	Qian Z, Carl ES, Dong DF, Yingchu H and Gregory H. Detrimental Effects of the Ketogenic Diet on Cognitive Function in Rats. International Pediatric Research Foundation, 2004: 55 (3), 498-506. doi: 10.1203/01.PDR.0000112032.47575.D1.
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[14]	Masino, S. A., Kawamura, J. M and Ruskin, D. N. Adenosine receptors and epilepsy: current evidence and future potential. Int Rev Neurobiol 2014: 119, 233–255.
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[16]	Calderón, N., Betancourt, L., Hernández, L. and Rada, P. A ketogenic diet modifies glutamate, gamma-aminobutyric acid and agmatine levels in the hippocampus of rats: A microdialysis study. Neuroscience Letters, 2017: 642, 158-162.
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Maryam Adenike Salaudeen, Mohammed Garba Magaji, Abdulkadir Umar Zezi. (2023). Modified Atkins Diet Delayed the Onset of Epileptogenesis, Improved Motor Coordination and Enhanced Learning Memory in Mice. American Journal of Bioscience and Bioengineering, 11(1), 1-6. https://doi.org/10.11648/j.bio.20231101.11

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ACS Style

Maryam Adenike Salaudeen; Mohammed Garba Magaji; Abdulkadir Umar Zezi. Modified Atkins Diet Delayed the Onset of Epileptogenesis, Improved Motor Coordination and Enhanced Learning Memory in Mice. Am. J. BioSci. Bioeng. 2023, 11(1), 1-6. doi: 10.11648/j.bio.20231101.11

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AMA Style

Maryam Adenike Salaudeen, Mohammed Garba Magaji, Abdulkadir Umar Zezi. Modified Atkins Diet Delayed the Onset of Epileptogenesis, Improved Motor Coordination and Enhanced Learning Memory in Mice. Am J BioSci Bioeng. 2023;11(1):1-6. doi: 10.11648/j.bio.20231101.11

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@article{10.11648/j.bio.20231101.11,
  author = {Maryam Adenike Salaudeen and Mohammed Garba Magaji and Abdulkadir Umar Zezi},
  title = {Modified Atkins Diet Delayed the Onset of Epileptogenesis, Improved Motor Coordination and Enhanced Learning Memory in Mice},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {11},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.bio.20231101.11},
  url = {https://doi.org/10.11648/j.bio.20231101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20231101.11},
  abstract = {Modified Atkins diet is a high fat, moderate protein and carbohydrate diet that has long been used to manage intractable epilepsy in developed countries. However, the use of this diet for same condition is uncommon in most low- and middle-income countries including Nigeria. In a previous research, we formulated modified Atkins diet using cheap and locally-available food materials in Nigeria. This research is thus, aimed at evaluating the effect of the formulated modified Atkins diet on seizure plasticity using the PTZ-induced kindling model of seizure. We also investigated the effect of sub-chronic use (60 days) of the diet on motor coordination using positional sense test and on visual-spatial reference and learning memory using Morris-water maze. The result revealed that the formulated modified Atkins diet significantly (p) increased seizure plasticity by reducing the severity of seizure as well as delaying the onset of tonic-clonic seizure and death. The diet also enhanced motor coordination, and improved learning memory, but not reference memory in mice. We therefore concluded that the formulated modified Atkins diet may be of benefit in the management of intractable/treatment-resistant epilepsy, especially in patients who are already suffering from amnesia and/or postural instability since the diet was able to offer protection against seizure-induced memory loss and motor-incoordination in mice.},
 year = {2023}
}

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TY  - JOUR
T1  - Modified Atkins Diet Delayed the Onset of Epileptogenesis, Improved Motor Coordination and Enhanced Learning Memory in Mice
AU  - Maryam Adenike Salaudeen
AU  - Mohammed Garba Magaji
AU  - Abdulkadir Umar Zezi
Y1  - 2023/03/04
PY  - 2023
N1  - https://doi.org/10.11648/j.bio.20231101.11
DO  - 10.11648/j.bio.20231101.11
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.20231101.11
AB  - Modified Atkins diet is a high fat, moderate protein and carbohydrate diet that has long been used to manage intractable epilepsy in developed countries. However, the use of this diet for same condition is uncommon in most low- and middle-income countries including Nigeria. In a previous research, we formulated modified Atkins diet using cheap and locally-available food materials in Nigeria. This research is thus, aimed at evaluating the effect of the formulated modified Atkins diet on seizure plasticity using the PTZ-induced kindling model of seizure. We also investigated the effect of sub-chronic use (60 days) of the diet on motor coordination using positional sense test and on visual-spatial reference and learning memory using Morris-water maze. The result revealed that the formulated modified Atkins diet significantly (p) increased seizure plasticity by reducing the severity of seizure as well as delaying the onset of tonic-clonic seizure and death. The diet also enhanced motor coordination, and improved learning memory, but not reference memory in mice. We therefore concluded that the formulated modified Atkins diet may be of benefit in the management of intractable/treatment-resistant epilepsy, especially in patients who are already suffering from amnesia and/or postural instability since the diet was able to offer protection against seizure-induced memory loss and motor-incoordination in mice.
VL  - 11
IS  - 1
ER  -

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Author Information

Maryam Adenike Salaudeen

Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria
Mohammed Garba Magaji

Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria
Abdulkadir Umar Zezi

Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria

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APA Style

Maryam Adenike Salaudeen, Mohammed Garba Magaji, Abdulkadir Umar Zezi. (2023). Modified Atkins Diet Delayed the Onset of Epileptogenesis, Improved Motor Coordination and Enhanced Learning Memory in Mice. American Journal of Bioscience and Bioengineering, 11(1), 1-6. https://doi.org/10.11648/j.bio.20231101.11

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ACS Style

Maryam Adenike Salaudeen; Mohammed Garba Magaji; Abdulkadir Umar Zezi. Modified Atkins Diet Delayed the Onset of Epileptogenesis, Improved Motor Coordination and Enhanced Learning Memory in Mice. Am. J. BioSci. Bioeng. 2023, 11(1), 1-6. doi: 10.11648/j.bio.20231101.11

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AMA Style

Maryam Adenike Salaudeen, Mohammed Garba Magaji, Abdulkadir Umar Zezi. Modified Atkins Diet Delayed the Onset of Epileptogenesis, Improved Motor Coordination and Enhanced Learning Memory in Mice. Am J BioSci Bioeng. 2023;11(1):1-6. doi: 10.11648/j.bio.20231101.11

Copy | Download

@article{10.11648/j.bio.20231101.11,
  author = {Maryam Adenike Salaudeen and Mohammed Garba Magaji and Abdulkadir Umar Zezi},
  title = {Modified Atkins Diet Delayed the Onset of Epileptogenesis, Improved Motor Coordination and Enhanced Learning Memory in Mice},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {11},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.bio.20231101.11},
  url = {https://doi.org/10.11648/j.bio.20231101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20231101.11},
  abstract = {Modified Atkins diet is a high fat, moderate protein and carbohydrate diet that has long been used to manage intractable epilepsy in developed countries. However, the use of this diet for same condition is uncommon in most low- and middle-income countries including Nigeria. In a previous research, we formulated modified Atkins diet using cheap and locally-available food materials in Nigeria. This research is thus, aimed at evaluating the effect of the formulated modified Atkins diet on seizure plasticity using the PTZ-induced kindling model of seizure. We also investigated the effect of sub-chronic use (60 days) of the diet on motor coordination using positional sense test and on visual-spatial reference and learning memory using Morris-water maze. The result revealed that the formulated modified Atkins diet significantly (p) increased seizure plasticity by reducing the severity of seizure as well as delaying the onset of tonic-clonic seizure and death. The diet also enhanced motor coordination, and improved learning memory, but not reference memory in mice. We therefore concluded that the formulated modified Atkins diet may be of benefit in the management of intractable/treatment-resistant epilepsy, especially in patients who are already suffering from amnesia and/or postural instability since the diet was able to offer protection against seizure-induced memory loss and motor-incoordination in mice.},
 year = {2023}
}

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TY  - JOUR
T1  - Modified Atkins Diet Delayed the Onset of Epileptogenesis, Improved Motor Coordination and Enhanced Learning Memory in Mice
AU  - Maryam Adenike Salaudeen
AU  - Mohammed Garba Magaji
AU  - Abdulkadir Umar Zezi
Y1  - 2023/03/04
PY  - 2023
N1  - https://doi.org/10.11648/j.bio.20231101.11
DO  - 10.11648/j.bio.20231101.11
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.20231101.11
AB  - Modified Atkins diet is a high fat, moderate protein and carbohydrate diet that has long been used to manage intractable epilepsy in developed countries. However, the use of this diet for same condition is uncommon in most low- and middle-income countries including Nigeria. In a previous research, we formulated modified Atkins diet using cheap and locally-available food materials in Nigeria. This research is thus, aimed at evaluating the effect of the formulated modified Atkins diet on seizure plasticity using the PTZ-induced kindling model of seizure. We also investigated the effect of sub-chronic use (60 days) of the diet on motor coordination using positional sense test and on visual-spatial reference and learning memory using Morris-water maze. The result revealed that the formulated modified Atkins diet significantly (p) increased seizure plasticity by reducing the severity of seizure as well as delaying the onset of tonic-clonic seizure and death. The diet also enhanced motor coordination, and improved learning memory, but not reference memory in mice. We therefore concluded that the formulated modified Atkins diet may be of benefit in the management of intractable/treatment-resistant epilepsy, especially in patients who are already suffering from amnesia and/or postural instability since the diet was able to offer protection against seizure-induced memory loss and motor-incoordination in mice.
VL  - 11
IS  - 1
ER  -

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