Human milk oligosaccharides (HMOs) contain numerous biomolecules. It is the third most abundant solid component of breast milk, after lactose and lipids, that plays an important role in infant growth and the development of human life. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, development of the immune system, increasing the intestinal barrier and so many health benefits can be achieved through the presence of HMOs in breast milk. Infant growth is indirectly or directly dependent on so many compounds of the biological and chemical composition of mother milk, HMOs are one of them. The genetic background of the mothers and the diversity of HMOs are determined and the non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefits than those of non-secretor mothers. Here the study critically reviewed the role of HMOs in proper growth, immune system, and development in ensuring the health impact of infants and toddlers. The study also focuses on current knowledge of the HMOs study and the beneficial effect of HMOs types and their importance to infant growth and protection against NEC. HMOs are applied now in infant formulas to imitative nutrition composition of breast milk and their study and challenges are vastly discussed in a specific manner in the human study. In conclusion, it is stated that the supplementation of infant formula with 2′-FL and LNnT is a promising innovation for infant nutrition.
| Published in | American Journal of Pediatrics (Volume 8, Issue 2) |
| DOI | 10.11648/j.ajp.20220802.18 |
| Page(s) | 98-103 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Human Milk Oligosaccharides, Intestinal Barrier, Micro-Biota, Anti Bacteria, Necrotizing Enterocolitis, Pathogen Infection
| [1] | Thurow R. The first 1,000 days: A crucial time for mothers and children—and the world. Breastfeeding Medicine. 2016 Oct 1; 11 (8): 416-8. |
| [2] | Haveri A, Smura T, Kuivanen S, Österlund P, Hepojoki J, Ikonen N, Pitkäpaasi M, Blomqvist S, Rönkkö E, Kantele A, Strandin T. Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020. Eurosurveillance. 2020 Mar 19; 25 (11): 2000266. |
| [3] | Bosi L, Giugni M, Uba K, editors. The consequences of social movements. Cambridge University Press; 2016 Jan 21. |
| [4] | Hamdy FC, Donovan JL, Lane J, Mason M, Metcalfe C, Holding P, Davis M, Peters TJ, Turner EL, Martin RM, Oxley J. 10-year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer. N Engl J Med. 2016 Oct 13; 375: 1415-24. |
| [5] | Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors. Pediatric Clinics. 2013 Feb 1; 60 (1): 49-74. |
| [6] | Puccio G, Alliet P, Cajozzo C, Janssens E, Corsello G, Sprenger N, Wernimont S, Egli D, Gosoniu L, Steenhout P. Effects of infant formula with human milk oligosaccharides on growth and morbidity: a randomized multicenter trial. Journal of pediatric gastroenterology and nutrition. 2017 Apr; 64 (4): 624. |
| [7] | Rosen R, Vandenplas Y, Singendonk M, Cabana M, Di Lorenzo C, Gottrand F, Gupta S, Langendam M, Staiano A, Thapar N, Tipnis N. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). Journal of pediatric gastroenterology and nutrition. 2018 Mar; 66 (3): 516. |
| [8] | Macpherson AJ, de Agüero MG, Ganal-Vonarburg SC. How nutrition and the maternal microbiota shape the neonatal immune system. Nature Reviews Immunology. 2017 Aug; 17 (8): 508-17. |
| [9] | Bode L. Human milk oligosaccharides: every baby needs a sugar mama. Glycobiology. 2012 Sep 1; 22 (9): 1147-62. |
| [10] | Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, Cedazo-Minguez A, Dubois B, Edvardsson D, Feldman H, Fratiglioni L. Defeating Alzheimer's disease and other dementias: a priority for European science and society. The Lancet Neurology. 2016 Apr 1; 15 (5): 455-532. |
| [11] | Kirmiz M, Vierra NC, Palacio S, Trimmer JS. Identification of VAPA and VAPB as Kv2 channel-interacting proteins defining endoplasmic reticulum–plasma membrane junctions in mammalian brain neurons. Journal of Neuroscience. 2018 Aug 29; 38 (35): 7562-84. |
| [12] | Gotoh H, Khayyer A. On the state-of-the-art of particle methods for coastal and ocean engineering. Coastal Engineering Journal. 2018 Jan 2; 60 (1): 79-103. |
| [13] | Schwab K. The fourth industrial revolution. Currency; 2017 Jan 3. |
| [14] | Patel V, Saxena S, Lund C, Thornicroft G, Baingana F, Bolton P, Chisholm D, Collins PY, Cooper JL, Eaton J, Herrman H. The Lancet Commission on global mental health and sustainable development. The Lancet. 2018 Oct 27; 392 (10157): 1553-98. |
| [15] | Al-Khatib SM, Stevenson WG, Ackerman MJ, Bryant WJ, Callans DJ, Curtis AB, Deal BJ, Dickfeld T, Field ME, Fonarow GC, Gillis AM. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Journal of the American College of Cardiology. 2018 Oct 2; 72 (14): e91-220. |
| [16] | Scharlemann JP, Tanner EV, Hiederer R, Kapos V. Global soil carbon: understanding and managing the largest terrestrial carbon pool. Carbon Management. 2014 Feb 1; 5 (1): 81-91. |
| [17] | Chichlowski M, Guillaume De Lartigue J, Raybould HE, Mills DA. Bifidobacteria isolated from infants and cultured on human milk oligosaccharides affect intestinal epithelial function. Journal of pediatric gastroenterology and nutrition. 2012 Sep; 55 (3): 321. |
| [18] | Meeker M, Wu L. Internet trends 2018. |
| [19] | Bottani E, Murino T, Schiavo M, Akkerman R. Resilient food supply chain design: Modelling framework and metaheuristic solution approach. Computers & Industrial Engineering. 2019 Sep 1; 135: 177-98. |
| [20] | Abbott BP, Abbott R, Abbott T, Abraham S, Acernese F, Ackley K, Adams C, Adhikari RX, Adya VB, Affeldt C, Agathos M. GWTC-1: a gravitational-wave transient catalog of compact binary mergers observed by LIGO and Virgo during the first and second observing runs. Physical Review X. 2019 Sep 4; 9 (3): 031040. |
| [21] | Panel AP. Power people planet: seizing Africa's energy and climate opportunities: Africa progress report 2015. |
| [22] | Cheng L, Akkerman R, Kong C, Walvoort MT, de Vos P. More than sugar in the milk: human milk oligosaccharides as essential bioactive molecules in breast milk and current insight in beneficial effects. Critical Reviews in Food Science and Nutrition. 2021 Mar 8; 61 (7): 1184-200. |
| [23] | Nassif ME, Windsor SL, Tang F, Khariton Y, Husain M, Inzucchi SE, McGuire DK, Pitt B, Scirica BM, Austin B, Drazner MH. Dapagliflozin effects on biomarkers, symptoms, and functional status in patients with heart failure with reduced ejection fraction: the DEFINE-HF trial. Circulation. 2019 Oct 29; 140 (18): 1463-76. |
| [24] | Šuligoj T, Vigsnæs LK, Abbeele PV, Apostolou A, Karalis K, Savva GM, McConnell B, Juge N. Effects of human milk oligosaccharides on the adult gut microbiota and barrier function. Nutrients. 2020 Sep; 12 (9): 2808. |
| [25] | Triantis V, Bode L, van Neerven RJ. Immunological effects of human milk oligosaccharides. Frontiers in pediatrics. 2018: 190. |
| [26] | Liu J, Bao Z, Cui Y, Dufek EJ, Goodenough JB, Khalifah P, Li Q, Liaw BY, Liu P, Manthiram A, Meng YS. Pathways for practical high-energy long-cycling lithium metal batteries. Nature Energy. 2019 Mar; 4 (3): 180-6. |
| [27] | Ayechu-Muruzabal V, Overbeek SA, Kostadinova AI, Stahl B, Garssen J, Van’T Land B, Willemsen LE. Exposure of intestinal epithelial cells to 2′-fucosyllactose and CpG enhances galectin release and instructs dendritic cells to drive Th1 and regulatory-type immune development. Biomolecules. 2020 May; 10 (5): 784. |
| [28] | Álvarez-Lerma F, Palomar-Martínez M, Sánchez-García M, Martínez-Alonso M, Álvarez-Rodríguez J, Lorente L, Arias-Rivera S, García R, Gordo F, Añón JM, Jam-Gatell R. Prevention of ventilator-associated pneumonia: the multimodal approach of the Spanish ICU “Pneumonia Zero” program. Critical care medicine. 2018 Feb; 46 (2): 181. |
| [29] | Lin TY, Maire M, Belongie S, Hays J, Perona P, Ramanan D, Dollár P, Zitnick CL. Microsoft coco: Common objects in context. InEuropean conference on computer vision 2014 Sep 6 (pp. 740-755). Springer, Cham. |
| [30] | Moubareck CA. Human milk microbiota and oligosaccharides: a glimpse into benefits, diversity, and correlations. Nutrients. 2021 Apr; 13 (4): 1123. |
| [31] | El-Hawiet A, Chen Y, Shams-Ud-Doha K, Kitova EN, St-Pierre Y, Klassen JS. High-throughput label-and immobilization-free screening of human milk oligosaccharides against lectins. Analytical chemistry. 2017 Sep 5; 89 (17): 8713-22. |
APA Style
Aftab Yusuf Raj, Rajesh Majumder, Fuadul Islam, ATM Rafique Uzzal, Kuntal Roy, et al. (2022). Role of Human Milk Oligosaccharides (HMOs) on Proper Growth, Immunity, and Tolerance in Ensuring Lifelong Health for Infants and Toddlers. American Journal of Pediatrics, 8(2), 98-103. https://doi.org/10.11648/j.ajp.20220802.18
ACS Style
Aftab Yusuf Raj; Rajesh Majumder; Fuadul Islam; ATM Rafique Uzzal; Kuntal Roy, et al. Role of Human Milk Oligosaccharides (HMOs) on Proper Growth, Immunity, and Tolerance in Ensuring Lifelong Health for Infants and Toddlers. Am. J. Pediatr. 2022, 8(2), 98-103. doi: 10.11648/j.ajp.20220802.18
AMA Style
Aftab Yusuf Raj, Rajesh Majumder, Fuadul Islam, ATM Rafique Uzzal, Kuntal Roy, et al. Role of Human Milk Oligosaccharides (HMOs) on Proper Growth, Immunity, and Tolerance in Ensuring Lifelong Health for Infants and Toddlers. Am J Pediatr. 2022;8(2):98-103. doi: 10.11648/j.ajp.20220802.18
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Download@article{10.11648/j.ajp.20220802.18,
author = {Aftab Yusuf Raj and Rajesh Majumder and Fuadul Islam and ATM Rafique Uzzal and Kuntal Roy and Kamrul Hasan and Sabira Rahman},
title = {Role of Human Milk Oligosaccharides (HMOs) on Proper Growth, Immunity, and Tolerance in Ensuring Lifelong Health for Infants and Toddlers},
journal = {American Journal of Pediatrics},
volume = {8},
number = {2},
pages = {98-103},
doi = {10.11648/j.ajp.20220802.18},
url = {https://doi.org/10.11648/j.ajp.20220802.18},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220802.18},
abstract = {Human milk oligosaccharides (HMOs) contain numerous biomolecules. It is the third most abundant solid component of breast milk, after lactose and lipids, that plays an important role in infant growth and the development of human life. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, development of the immune system, increasing the intestinal barrier and so many health benefits can be achieved through the presence of HMOs in breast milk. Infant growth is indirectly or directly dependent on so many compounds of the biological and chemical composition of mother milk, HMOs are one of them. The genetic background of the mothers and the diversity of HMOs are determined and the non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefits than those of non-secretor mothers. Here the study critically reviewed the role of HMOs in proper growth, immune system, and development in ensuring the health impact of infants and toddlers. The study also focuses on current knowledge of the HMOs study and the beneficial effect of HMOs types and their importance to infant growth and protection against NEC. HMOs are applied now in infant formulas to imitative nutrition composition of breast milk and their study and challenges are vastly discussed in a specific manner in the human study. In conclusion, it is stated that the supplementation of infant formula with 2′-FL and LNnT is a promising innovation for infant nutrition.},
year = {2022}
}
TY - JOUR T1 - Role of Human Milk Oligosaccharides (HMOs) on Proper Growth, Immunity, and Tolerance in Ensuring Lifelong Health for Infants and Toddlers AU - Aftab Yusuf Raj AU - Rajesh Majumder AU - Fuadul Islam AU - ATM Rafique Uzzal AU - Kuntal Roy AU - Kamrul Hasan AU - Sabira Rahman Y1 - 2022/04/29 PY - 2022 N1 - https://doi.org/10.11648/j.ajp.20220802.18 DO - 10.11648/j.ajp.20220802.18 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 98 EP - 103 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20220802.18 AB - Human milk oligosaccharides (HMOs) contain numerous biomolecules. It is the third most abundant solid component of breast milk, after lactose and lipids, that plays an important role in infant growth and the development of human life. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, development of the immune system, increasing the intestinal barrier and so many health benefits can be achieved through the presence of HMOs in breast milk. Infant growth is indirectly or directly dependent on so many compounds of the biological and chemical composition of mother milk, HMOs are one of them. The genetic background of the mothers and the diversity of HMOs are determined and the non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefits than those of non-secretor mothers. Here the study critically reviewed the role of HMOs in proper growth, immune system, and development in ensuring the health impact of infants and toddlers. The study also focuses on current knowledge of the HMOs study and the beneficial effect of HMOs types and their importance to infant growth and protection against NEC. HMOs are applied now in infant formulas to imitative nutrition composition of breast milk and their study and challenges are vastly discussed in a specific manner in the human study. In conclusion, it is stated that the supplementation of infant formula with 2′-FL and LNnT is a promising innovation for infant nutrition. VL - 8 IS - 2 ER -
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