Background: The synthesis of new heterocyclic derivatives has attracted considerable attention. The explosive growth of heterocyclic chemistry is emphasized by the large number of research publications, monographs, and reviews. The heterocyclic organic compounds are extensively disseminated in natural and synthetic medicinal chemistry and are vital for human life. Looking at the previous studies on quinazolinones derivatives, only limited information is available on their mass spectral along with the preparation of novel quinazolin-4-(3H)-one derivatives. Objective: Aspiration of this investigation, was to synthesize a new 3-Amino-2-Methyl-6-methoxy-quinazolin-4-one was synthesized via the reaction between 2-Methyl-6-methoxy-benzo-1,3-oxazin-4-one and hydrazine hydrate and investigate their electron impact (EI) mass spectral disintegration. Method: The consolidation of 2-amino-methyl-5methoxybenzoate with acetic anhydride yielded the cyclic compound 2- methyl-4, 5-disubstituted-1, 3-benzo-oxazine-4-one which then produce a novel 2,3-disubstituted quinazolin-4 ones via the reaction with hydrazine hydrate. The compounds synthesized were enormously confirmed by means of Infrared, Nuclear Magnetic Resonance (1H and 13C), Gas Chromatography Mass Spectrophotometer and Elemental analysis. Discussion: The molecular ion of m/z 205 splints to give m/z 190 by loss of –NH group. The ion of m/z 190 was broken to give m/z 177 by losing CH group. This fragmented to m/z 162 by loss of –CH3 group and then m/z 136 by loss of CN group. The loss of O gave m/z 120 which fragment to give m/z 93 by loss of –HCN and finally gave m/z 65 by loss of CO group. Conclusion: The electron impact ionization mass spectra of compound 2 show a weak molecular ion peak and a base peak ofm/z 205 resulting from a break up fragmentation. Compound 2 give a characteristic fragmentation pattern. From the examination of the mass spectra of compound 2, it was found that the molecular ion had fragmented to the m/z 190. The final disintegration led to ion of m/z 93 and ion of mass m/z 65, respectively.
| Published in | American Journal of Materials Synthesis and Processing (Volume 7, Issue 1) |
| DOI | 10.11648/j.ajmsp.20220701.12 |
| Page(s) | 8-14 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Mass Spectroscopy, Synthesis, Quinazoline-4-One, 2-Methyl 6-subtituted 1, 3-Benzo-Oxazine-4-One, 3-Amino-2-Methyl-6-methoxy-quinazolin-4-one, Nucleophile, Electron Impact Ionization Mass Spectra
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APA Style
Osarumwense Peter Osarodion, Ayedun Hassan, Arigbede John. (2022). An Electron Bombardment Photodisintegration Spectrum Analysis of 3-Amino 6-methoxyl-2-MethylQuinazolin-4-(3H)-one Derivative. American Journal of Materials Synthesis and Processing, 7(1), 8-14. https://doi.org/10.11648/j.ajmsp.20220701.12
ACS Style
Osarumwense Peter Osarodion; Ayedun Hassan; Arigbede John. An Electron Bombardment Photodisintegration Spectrum Analysis of 3-Amino 6-methoxyl-2-MethylQuinazolin-4-(3H)-one Derivative. Am. J. Mater. Synth. Process. 2022, 7(1), 8-14. doi: 10.11648/j.ajmsp.20220701.12
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Download@article{10.11648/j.ajmsp.20220701.12,
author = {Osarumwense Peter Osarodion and Ayedun Hassan and Arigbede John},
title = {An Electron Bombardment Photodisintegration Spectrum Analysis of 3-Amino 6-methoxyl-2-MethylQuinazolin-4-(3H)-one Derivative},
journal = {American Journal of Materials Synthesis and Processing},
volume = {7},
number = {1},
pages = {8-14},
doi = {10.11648/j.ajmsp.20220701.12},
url = {https://doi.org/10.11648/j.ajmsp.20220701.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajmsp.20220701.12},
abstract = {Background: The synthesis of new heterocyclic derivatives has attracted considerable attention. The explosive growth of heterocyclic chemistry is emphasized by the large number of research publications, monographs, and reviews. The heterocyclic organic compounds are extensively disseminated in natural and synthetic medicinal chemistry and are vital for human life. Looking at the previous studies on quinazolinones derivatives, only limited information is available on their mass spectral along with the preparation of novel quinazolin-4-(3H)-one derivatives. Objective: Aspiration of this investigation, was to synthesize a new 3-Amino-2-Methyl-6-methoxy-quinazolin-4-one was synthesized via the reaction between 2-Methyl-6-methoxy-benzo-1,3-oxazin-4-one and hydrazine hydrate and investigate their electron impact (EI) mass spectral disintegration. Method: The consolidation of 2-amino-methyl-5methoxybenzoate with acetic anhydride yielded the cyclic compound 2- methyl-4, 5-disubstituted-1, 3-benzo-oxazine-4-one which then produce a novel 2,3-disubstituted quinazolin-4 ones via the reaction with hydrazine hydrate. The compounds synthesized were enormously confirmed by means of Infrared, Nuclear Magnetic Resonance (1H and 13C), Gas Chromatography Mass Spectrophotometer and Elemental analysis. Discussion: The molecular ion of m/z 205 splints to give m/z 190 by loss of –NH group. The ion of m/z 190 was broken to give m/z 177 by losing CH group. This fragmented to m/z 162 by loss of –CH3 group and then m/z 136 by loss of CN group. The loss of O gave m/z 120 which fragment to give m/z 93 by loss of –HCN and finally gave m/z 65 by loss of CO group. Conclusion: The electron impact ionization mass spectra of compound 2 show a weak molecular ion peak and a base peak ofm/z 205 resulting from a break up fragmentation. Compound 2 give a characteristic fragmentation pattern. From the examination of the mass spectra of compound 2, it was found that the molecular ion had fragmented to the m/z 190. The final disintegration led to ion of m/z 93 and ion of mass m/z 65, respectively.},
year = {2022}
}
TY - JOUR T1 - An Electron Bombardment Photodisintegration Spectrum Analysis of 3-Amino 6-methoxyl-2-MethylQuinazolin-4-(3H)-one Derivative AU - Osarumwense Peter Osarodion AU - Ayedun Hassan AU - Arigbede John Y1 - 2022/03/12 PY - 2022 N1 - https://doi.org/10.11648/j.ajmsp.20220701.12 DO - 10.11648/j.ajmsp.20220701.12 T2 - American Journal of Materials Synthesis and Processing JF - American Journal of Materials Synthesis and Processing JO - American Journal of Materials Synthesis and Processing SP - 8 EP - 14 PB - Science Publishing Group SN - 2575-1530 UR - https://doi.org/10.11648/j.ajmsp.20220701.12 AB - Background: The synthesis of new heterocyclic derivatives has attracted considerable attention. The explosive growth of heterocyclic chemistry is emphasized by the large number of research publications, monographs, and reviews. The heterocyclic organic compounds are extensively disseminated in natural and synthetic medicinal chemistry and are vital for human life. Looking at the previous studies on quinazolinones derivatives, only limited information is available on their mass spectral along with the preparation of novel quinazolin-4-(3H)-one derivatives. Objective: Aspiration of this investigation, was to synthesize a new 3-Amino-2-Methyl-6-methoxy-quinazolin-4-one was synthesized via the reaction between 2-Methyl-6-methoxy-benzo-1,3-oxazin-4-one and hydrazine hydrate and investigate their electron impact (EI) mass spectral disintegration. Method: The consolidation of 2-amino-methyl-5methoxybenzoate with acetic anhydride yielded the cyclic compound 2- methyl-4, 5-disubstituted-1, 3-benzo-oxazine-4-one which then produce a novel 2,3-disubstituted quinazolin-4 ones via the reaction with hydrazine hydrate. The compounds synthesized were enormously confirmed by means of Infrared, Nuclear Magnetic Resonance (1H and 13C), Gas Chromatography Mass Spectrophotometer and Elemental analysis. Discussion: The molecular ion of m/z 205 splints to give m/z 190 by loss of –NH group. The ion of m/z 190 was broken to give m/z 177 by losing CH group. This fragmented to m/z 162 by loss of –CH3 group and then m/z 136 by loss of CN group. The loss of O gave m/z 120 which fragment to give m/z 93 by loss of –HCN and finally gave m/z 65 by loss of CO group. Conclusion: The electron impact ionization mass spectra of compound 2 show a weak molecular ion peak and a base peak ofm/z 205 resulting from a break up fragmentation. Compound 2 give a characteristic fragmentation pattern. From the examination of the mass spectra of compound 2, it was found that the molecular ion had fragmented to the m/z 190. The final disintegration led to ion of m/z 93 and ion of mass m/z 65, respectively. VL - 7 IS - 1 ER -
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