Clinicopathological Analysis of 2 Cases of Intracranial Mesenchymal Chondrosarcoma

Liang Juan; Qian Lu; Xue Fenglin; Li Ting; Zhou Hongping; Bian Li

doi:doi:10.11648/j.ajcem.20221006.11

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Clinicopathological Analysis of 2 Cases of Intracranial Mesenchymal Chondrosarcoma

Liang Juan, Qian Lu, Xue Fenglin, Li Ting, Zhou Hongping, Bian Li

Published in American Journal of Clinical and Experimental Medicine (Volume 10, Issue 6)

Received: 1 November 2022 Accepted: 23 November 2022 Published: 30 November 2022

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Abstract

Objective To analyze the clinical imaging data, pathological manifestations, molecular genetic characteristics and treatment of intracranial mesenchymal chondrosarcoma (MC), and to explore its diagnosis, differential diagnosis basis and clinical treatment plan. Methods The clinicopathological features, imaging data and immunophenotype of 2 cases of intracranial MC were retrospectively analyzed, and related literatures were reviewed. Results Both patients were admitted to hospital because of headache and limited vision. Imaging examination showed intracranial and extracerebral lesions (possible meningioma?). Microscopically, the tumor showed bidirectional differentiation and consisted of small round undifferentiated mesenchymal cells with basically the same size and scattered islands of relatively mature hyaline cartilage. Hemangiopericytoma conformation was seen in some areas. Immunophenotype: small round cells CD99 and vimentin (+), Ki-67 proliferation index 15% to 30%, PCK, Syn and NSE (-), chondrocytes S-100 (+), local expression of cartilage matrix collagen II. Conclusion Primary intracranial MC is extremely rare and easy to be misdiagnosed. It needs to be compared with meningiomas, extraosseous Ewing's sarcoma, solitary fibrous tumor/hemangiopericytoma, soft tissue malignant lymphoma, small cell metastatic carcinoma and other types of chondrosarcoma. Phase identification.

Published in	American Journal of Clinical and Experimental Medicine (Volume 10, Issue 6)
DOI	10.11648/j.ajcem.20221006.11
Page(s)	124-128
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Intracranial Tumor, Mesenchymal Chondrosarcoma, Clinicopathological Features

References

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[15]	Atsuhito U, Kazuhito K, Atsushi F et al.Intracranial Mesenchymal Chondrosarcoma Lacking the Typical Histopathological Features Diagnosed by HEY1-NCOA2 Gene Fusion [J]. NMC Case Report Journal 2020; 7: 47-52.
[16]	Bloch OG, Jian BJ, Yang I et al.A systematic review of Intracranial Mesenchymal Chondrosarcoma and survival.J Clin Neurosci.2015; 16 (12): 1547-51.
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APA Style

Liang Juan, Qian Lu, Xue Fenglin, Li Ting, Zhou Hongping, et al. (2022). Clinicopathological Analysis of 2 Cases of Intracranial Mesenchymal Chondrosarcoma. American Journal of Clinical and Experimental Medicine, 10(6), 124-128. https://doi.org/10.11648/j.ajcem.20221006.11

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ACS Style

Liang Juan; Qian Lu; Xue Fenglin; Li Ting; Zhou Hongping, et al. Clinicopathological Analysis of 2 Cases of Intracranial Mesenchymal Chondrosarcoma. Am. J. Clin. Exp. Med. 2022, 10(6), 124-128. doi: 10.11648/j.ajcem.20221006.11

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AMA Style

Liang Juan, Qian Lu, Xue Fenglin, Li Ting, Zhou Hongping, et al. Clinicopathological Analysis of 2 Cases of Intracranial Mesenchymal Chondrosarcoma. Am J Clin Exp Med. 2022;10(6):124-128. doi: 10.11648/j.ajcem.20221006.11

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@article{10.11648/j.ajcem.20221006.11,
  author = {Liang Juan and Qian Lu and Xue Fenglin and Li Ting and Zhou Hongping and Bian Li},
  title = {Clinicopathological Analysis of 2 Cases of Intracranial Mesenchymal Chondrosarcoma},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {10},
  number = {6},
  pages = {124-128},
  doi = {10.11648/j.ajcem.20221006.11},
  url = {https://doi.org/10.11648/j.ajcem.20221006.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20221006.11},
  abstract = {Objective To analyze the clinical imaging data, pathological manifestations, molecular genetic characteristics and treatment of intracranial mesenchymal chondrosarcoma (MC), and to explore its diagnosis, differential diagnosis basis and clinical treatment plan. Methods The clinicopathological features, imaging data and immunophenotype of 2 cases of intracranial MC were retrospectively analyzed, and related literatures were reviewed. Results Both patients were admitted to hospital because of headache and limited vision. Imaging examination showed intracranial and extracerebral lesions (possible meningioma?). Microscopically, the tumor showed bidirectional differentiation and consisted of small round undifferentiated mesenchymal cells with basically the same size and scattered islands of relatively mature hyaline cartilage. Hemangiopericytoma conformation was seen in some areas. Immunophenotype: small round cells CD99 and vimentin (+), Ki-67 proliferation index 15% to 30%, PCK, Syn and NSE (-), chondrocytes S-100 (+), local expression of cartilage matrix collagen II. Conclusion Primary intracranial MC is extremely rare and easy to be misdiagnosed. It needs to be compared with meningiomas, extraosseous Ewing's sarcoma, solitary fibrous tumor/hemangiopericytoma, soft tissue malignant lymphoma, small cell metastatic carcinoma and other types of chondrosarcoma. Phase identification.},
 year = {2022}
}

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TY  - JOUR
T1  - Clinicopathological Analysis of 2 Cases of Intracranial Mesenchymal Chondrosarcoma
AU  - Liang Juan
AU  - Qian Lu
AU  - Xue Fenglin
AU  - Li Ting
AU  - Zhou Hongping
AU  - Bian Li
Y1  - 2022/11/30
PY  - 2022
N1  - https://doi.org/10.11648/j.ajcem.20221006.11
DO  - 10.11648/j.ajcem.20221006.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 124
EP  - 128
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20221006.11
AB  - Objective To analyze the clinical imaging data, pathological manifestations, molecular genetic characteristics and treatment of intracranial mesenchymal chondrosarcoma (MC), and to explore its diagnosis, differential diagnosis basis and clinical treatment plan. Methods The clinicopathological features, imaging data and immunophenotype of 2 cases of intracranial MC were retrospectively analyzed, and related literatures were reviewed. Results Both patients were admitted to hospital because of headache and limited vision. Imaging examination showed intracranial and extracerebral lesions (possible meningioma?). Microscopically, the tumor showed bidirectional differentiation and consisted of small round undifferentiated mesenchymal cells with basically the same size and scattered islands of relatively mature hyaline cartilage. Hemangiopericytoma conformation was seen in some areas. Immunophenotype: small round cells CD99 and vimentin (+), Ki-67 proliferation index 15% to 30%, PCK, Syn and NSE (-), chondrocytes S-100 (+), local expression of cartilage matrix collagen II. Conclusion Primary intracranial MC is extremely rare and easy to be misdiagnosed. It needs to be compared with meningiomas, extraosseous Ewing's sarcoma, solitary fibrous tumor/hemangiopericytoma, soft tissue malignant lymphoma, small cell metastatic carcinoma and other types of chondrosarcoma. Phase identification.
VL  - 10
IS  - 6
ER  -

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Author Information

Liang Juan

Department of Pathology, Diannan Central Hospital of Yunnan Prov
Qian Lu

Department of Pathology, The First Affiliated Hospital of Kunmin
Xue Fenglin

Department of Pathology, The First Affiliated Hospital of Kunmin
Li Ting

Department of Pathology, The First Affiliated Hospital of Kunmin
Zhou Hongping

Department of Pathology, The First Affiliated Hospital of Kunmin
Bian Li

Department of Pathology, The First Affiliated Hospital of Kunmin

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Plain Text BibTeX RIS

APA Style

Liang Juan, Qian Lu, Xue Fenglin, Li Ting, Zhou Hongping, et al. (2022). Clinicopathological Analysis of 2 Cases of Intracranial Mesenchymal Chondrosarcoma. American Journal of Clinical and Experimental Medicine, 10(6), 124-128. https://doi.org/10.11648/j.ajcem.20221006.11

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ACS Style

Liang Juan; Qian Lu; Xue Fenglin; Li Ting; Zhou Hongping, et al. Clinicopathological Analysis of 2 Cases of Intracranial Mesenchymal Chondrosarcoma. Am. J. Clin. Exp. Med. 2022, 10(6), 124-128. doi: 10.11648/j.ajcem.20221006.11

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AMA Style

Liang Juan, Qian Lu, Xue Fenglin, Li Ting, Zhou Hongping, et al. Clinicopathological Analysis of 2 Cases of Intracranial Mesenchymal Chondrosarcoma. Am J Clin Exp Med. 2022;10(6):124-128. doi: 10.11648/j.ajcem.20221006.11

Copy | Download

@article{10.11648/j.ajcem.20221006.11,
  author = {Liang Juan and Qian Lu and Xue Fenglin and Li Ting and Zhou Hongping and Bian Li},
  title = {Clinicopathological Analysis of 2 Cases of Intracranial Mesenchymal Chondrosarcoma},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {10},
  number = {6},
  pages = {124-128},
  doi = {10.11648/j.ajcem.20221006.11},
  url = {https://doi.org/10.11648/j.ajcem.20221006.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20221006.11},
  abstract = {Objective To analyze the clinical imaging data, pathological manifestations, molecular genetic characteristics and treatment of intracranial mesenchymal chondrosarcoma (MC), and to explore its diagnosis, differential diagnosis basis and clinical treatment plan. Methods The clinicopathological features, imaging data and immunophenotype of 2 cases of intracranial MC were retrospectively analyzed, and related literatures were reviewed. Results Both patients were admitted to hospital because of headache and limited vision. Imaging examination showed intracranial and extracerebral lesions (possible meningioma?). Microscopically, the tumor showed bidirectional differentiation and consisted of small round undifferentiated mesenchymal cells with basically the same size and scattered islands of relatively mature hyaline cartilage. Hemangiopericytoma conformation was seen in some areas. Immunophenotype: small round cells CD99 and vimentin (+), Ki-67 proliferation index 15% to 30%, PCK, Syn and NSE (-), chondrocytes S-100 (+), local expression of cartilage matrix collagen II. Conclusion Primary intracranial MC is extremely rare and easy to be misdiagnosed. It needs to be compared with meningiomas, extraosseous Ewing's sarcoma, solitary fibrous tumor/hemangiopericytoma, soft tissue malignant lymphoma, small cell metastatic carcinoma and other types of chondrosarcoma. Phase identification.},
 year = {2022}
}

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TY  - JOUR
T1  - Clinicopathological Analysis of 2 Cases of Intracranial Mesenchymal Chondrosarcoma
AU  - Liang Juan
AU  - Qian Lu
AU  - Xue Fenglin
AU  - Li Ting
AU  - Zhou Hongping
AU  - Bian Li
Y1  - 2022/11/30
PY  - 2022
N1  - https://doi.org/10.11648/j.ajcem.20221006.11
DO  - 10.11648/j.ajcem.20221006.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 124
EP  - 128
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20221006.11
AB  - Objective To analyze the clinical imaging data, pathological manifestations, molecular genetic characteristics and treatment of intracranial mesenchymal chondrosarcoma (MC), and to explore its diagnosis, differential diagnosis basis and clinical treatment plan. Methods The clinicopathological features, imaging data and immunophenotype of 2 cases of intracranial MC were retrospectively analyzed, and related literatures were reviewed. Results Both patients were admitted to hospital because of headache and limited vision. Imaging examination showed intracranial and extracerebral lesions (possible meningioma?). Microscopically, the tumor showed bidirectional differentiation and consisted of small round undifferentiated mesenchymal cells with basically the same size and scattered islands of relatively mature hyaline cartilage. Hemangiopericytoma conformation was seen in some areas. Immunophenotype: small round cells CD99 and vimentin (+), Ki-67 proliferation index 15% to 30%, PCK, Syn and NSE (-), chondrocytes S-100 (+), local expression of cartilage matrix collagen II. Conclusion Primary intracranial MC is extremely rare and easy to be misdiagnosed. It needs to be compared with meningiomas, extraosseous Ewing's sarcoma, solitary fibrous tumor/hemangiopericytoma, soft tissue malignant lymphoma, small cell metastatic carcinoma and other types of chondrosarcoma. Phase identification.
VL  - 10
IS  - 6
ER  -

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