The Effect of the Combined Use of Mechanical and Drug Revascularization in Acute Coronary Syndrome in Patients Working in Environmentally Polluted Conditions

Tarana Mammadhasan Javadova; Mammadhasan Mammadhuseyn Agayev

doi:doi:10.11648/j.ajcem.20221005.11

| Peer-Reviewed

The Effect of the Combined Use of Mechanical and Drug Revascularization in Acute Coronary Syndrome in Patients Working in Environmentally Polluted Conditions

Tarana Mammadhasan Javadova, Mammadhasan Mammadhuseyn Agayev

Published in American Journal of Clinical and Experimental Medicine (Volume 10, Issue 5)

Received: 6 July 2022 Accepted: 8 August 2022 Published: 14 September 2022

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

The aim of the study was to evaluate the effect of the complex use of cardiotex (meldonium), obzidan (propranolol), cyto-mac, cardiket, preductal OD, ARBII, in combination with percutaneous intervention (PCI) and separately performed PCI on ecoendotoxicosis (AMP), on hemodynamics, cardiodynamics and clinical course of non-ST elevation acute coronary syndrome (NSTE ACS). The results of complex medical and mechanical revascularization and separately performed PCI were compared. The study included 63 patients with NSTE ACS aged 35 to 65 years (56.7 ± 1.20) (50 (79.4%) men, 13 (20.6%) women) and randomized into 3 groups (21 people each). 1st group got cardiotex, cyto-mac, obzidan (propranolol) were given anti-ischemic, isosorbidedinitrate (cardiket), antihypoxant - a biologically active food supplement vascard and PCI was performed. In group 2, cytomac and obzidan (propranolol), cardiotex were administered, anti-ischemic, antihypoxant –vascard, preductal OD, ARBII - losartan were given and PCI was performed a day later; in the 3rd group, only PCI was performed. All patients got heparin according to the schemes. During hospitalization and within a year after discharge drug therapy was carried out, including aspirin-cardio+clopidogril. At the same time, 2 times a year for 3 months, one capsule of vascard was taken once a day, one tablet of preductal OD once a day+losartan 12.5 (25) mg once a day, cardiotex was administered intravenously at 500 mg once per day for 15 days. In all groups, the degree of ecoendotoxicosis was determined in the blood, using echocardiography and Doppler echocardiography, the values of end systolic (ESV) and end diastolic (EDV) volumes, ejection fraction (EF), stroke index (SI), cardiac index (CI), local contractility disorder index (LCDI) of the left ventricle, restenosis-with the help of repeated coronary angiography, ECG for ST-segment elevation and repeated anginal pain. The dynamics of BPs and BPd and the clinical course of NSTE ACS were established. In patients of all groups the dynamics of BPs and BPd was recorded, indicators stabilized central hemodynamics. By reducing the degree of ecoendotoxicosis, EDV and ESV, LCDI, LV systolic function improves, EF increases (group 1-2). However, in the first and third groups, single ventricular extrasystoles were recorded in one patient. AHF was recorded in one patient In patients of 1st group. In the PCI-only group, 2 patients developed recurrent NT ACS, 3 had restenosis, 3 had AHF, and 2 patients died. The results of this study show that the complex use of drug therapy with PCI allows to get a prognostically positive result, in contrast to a separate PCI therapy.

Published in	American Journal of Clinical and Experimental Medicine (Volume 10, Issue 5)
DOI	10.11648/j.ajcem.20221005.11
Page(s)	107-114
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

NSTE ACS, Ecoendotoxicosis (AMP), Drug Therapy+PCI, Central Hemodynamics, Cardiohemodynamics, Clinical Course

References

[1]	Ageev F. T., Mareev V. Y. Fosinopril in the treatment of cardiovascular diseases. Clinical pharmacology, 2000, v. 8, №2, p. 94-98.
[2]	Agayev M. M. Clinical efficacy of fosinopril, propranolol and heparin during inpatient rehabilitation of patients with myocardial infarction. Clinical medicine, 2008, №3, p. 58-64.
[3]	Agayev M. M., Agayeva T. M. Evaluation of the effect of drug and mechanical revascularization in complex therapy in the acute period of myocardial infarction. Сurierul medical, 2014, №5, p. 25-29.
[4]	Golikov A. P., Gazaryan G. A., Zakharov I. V. Early and delayed percutaneous coronary interventions in the acute period of myocardial infarction. Cardiology, 2011, №11, p. 10-15.
[5]	Hygienic criteria for the state of the environment. Translation from English (WHO, Geneva). М.: Medicine, 2001, p. 85.
[6]	Dajo R. Ecology and life safety. Edited by Murovey: Progress, 2002, p. 447.
[7]	Jukova L. A., Shestakova N. M., Lupachev V. F., Alpatova T. N. Cardiovascular system in greenhouse workers // Issues of environmental hygiene and public health. All-Russian Scientific Society of Hygienists and Sanitary Doctors. Ryazan: 2008, p. 31-48.
[8]	Jirov I. V., Melichenko Y. V. Ramipril in the treatment of patients with acute myocardial infarction. Rational pharmacotherapy in cardiology, 2007, Moscow, № 4, p. 58-60.
[9]	Lopatin Y. M., Dronova Y. P. Clinical-pharmaco-economic aspects of the use of β-blockers in patients with coronary artery disease undergoing coronary bypass surgery. Cardiology, 2010, № 9, p. 15-22.
[10]	Lipatova V. I. Experience in using the indicator of average blood molecules for the diagnosis of morphological diseases in children. Laboratory work, 2014, №3, p. 138-140.
[11]	Parnes Y. Y., Gavrilova S. A. About the possibility of using lornoxicam in patients with ST-segment elevation myocardial infarction. Cardiology, 2011, №3, p. 31-35.
[12]	Ruda M. Y. Acute coronary syndrome: a system for organizing treatment. Cardiology, 2011, №3, p. 4-9.
[13]	Sydorenko B. A., Preobrajenkiy V. D. The place of modern angiotensin-converting enzyme inhibitors in the treatment of cardiovascular pathology. Cardiology, 2000, №10, p. 91-103.
[14]	Shilov A. M. Antioxidants and antihypoxicants in cardiology practice. Russian Medical Journal, 2004, v. 12, №2, p. 5-12.
[15]	Аммоn D. R., Ertl G. Post acute myocardial infarction. The Cyto-Mack in acute myocardial infarction. Amer. Heart J., 2001, v. 138, p. 1651-1872.
[16]	Bekst R., Huchsermeyer H. Long-term therapy with Cyto-Mack. Fortschr. Med., 2005, Bd. 107, No 19, p. 423-427.
[17]	Hofman R., Mintz G. S. (2002). Coronary in-stent restenosis – predictive treatment and prevention. European Heart Journal. 21.1739-1749.
[18]	Kang S. Yang Y. (2007) Coronary microvаscular reperfusion injury and no-reflow in acute myocardial infarction. Clin Invest Med. 30: 133-145.
[19]	PoldermansD., Baks J. J., Boersma E. et al. (2009). Guidelines for preoperative cardiac risk assessment and perioperative cardiac surgery. European Heart Journal. 30: 2769-2812.
[20]	Sharma S. K., Kini A., Marmur J. D., Fuster V. (2000) Cardioprotective effect of prior β-blocker therapy in reducing creatin-kinase-MB elevation after coronary intervention. Circulation. 102: 166-172.
[21]	Werhengt F. W., Gersh B. I., Armistrong P. W. (2006) Aborted myocardial infarction a new target for reperfusion therapy. European Heart Journal, 27: 901-904.
[22]	Boden W. A., Feldman P. L., Gilles Th. Myocardial metabolism in ischemic heart disease. Proc. Cardiovasc. dis., 2001, v. 32, № 3. P. 217-238.

Cite This Article

Plain Text BibTeX RIS

APA Style

Tarana Mammadhasan Javadova, Mammadhasan Mammadhuseyn Agayev. (2022). The Effect of the Combined Use of Mechanical and Drug Revascularization in Acute Coronary Syndrome in Patients Working in Environmentally Polluted Conditions. American Journal of Clinical and Experimental Medicine, 10(5), 107-114. https://doi.org/10.11648/j.ajcem.20221005.11

Copy | Download

ACS Style

Tarana Mammadhasan Javadova; Mammadhasan Mammadhuseyn Agayev. The Effect of the Combined Use of Mechanical and Drug Revascularization in Acute Coronary Syndrome in Patients Working in Environmentally Polluted Conditions. Am. J. Clin. Exp. Med. 2022, 10(5), 107-114. doi: 10.11648/j.ajcem.20221005.11

Copy | Download

AMA Style

Tarana Mammadhasan Javadova, Mammadhasan Mammadhuseyn Agayev. The Effect of the Combined Use of Mechanical and Drug Revascularization in Acute Coronary Syndrome in Patients Working in Environmentally Polluted Conditions. Am J Clin Exp Med. 2022;10(5):107-114. doi: 10.11648/j.ajcem.20221005.11

Copy | Download

@article{10.11648/j.ajcem.20221005.11,
  author = {Tarana Mammadhasan Javadova and Mammadhasan Mammadhuseyn Agayev},
  title = {The Effect of the Combined Use of Mechanical and Drug Revascularization in Acute Coronary Syndrome in Patients Working in Environmentally Polluted Conditions},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {10},
  number = {5},
  pages = {107-114},
  doi = {10.11648/j.ajcem.20221005.11},
  url = {https://doi.org/10.11648/j.ajcem.20221005.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20221005.11},
  abstract = {The aim of the study was to evaluate the effect of the complex use of cardiotex (meldonium), obzidan (propranolol), cyto-mac, cardiket, preductal OD, ARBII, in combination with percutaneous intervention (PCI) and separately performed PCI on ecoendotoxicosis (AMP), on hemodynamics, cardiodynamics and clinical course of non-ST elevation acute coronary syndrome (NSTE ACS). The results of complex medical and mechanical revascularization and separately performed PCI were compared. The study included 63 patients with NSTE ACS aged 35 to 65 years (56.7 ± 1.20) (50 (79.4%) men, 13 (20.6%) women) and randomized into 3 groups (21 people each). 1st group got cardiotex, cyto-mac, obzidan (propranolol) were given anti-ischemic, isosorbidedinitrate (cardiket), antihypoxant - a biologically active food supplement vascard and PCI was performed. In group 2, cytomac and obzidan (propranolol), cardiotex were administered, anti-ischemic, antihypoxant –vascard, preductal OD, ARBII - losartan were given and PCI was performed a day later; in the 3rd group, only PCI was performed. All patients got heparin according to the schemes. During hospitalization and within a year after discharge drug therapy was carried out, including aspirin-cardio+clopidogril. At the same time, 2 times a year for 3 months, one capsule of vascard was taken once a day, one tablet of preductal OD once a day+losartan 12.5 (25) mg once a day, cardiotex was administered intravenously at 500 mg once per day for 15 days. In all groups, the degree of ecoendotoxicosis was determined in the blood, using echocardiography and Doppler echocardiography, the values of end systolic (ESV) and end diastolic (EDV) volumes, ejection fraction (EF), stroke index (SI), cardiac index (CI), local contractility disorder index (LCDI) of the left ventricle, restenosis-with the help of repeated coronary angiography, ECG for ST-segment elevation and repeated anginal pain. The dynamics of BPs and BPd and the clinical course of NSTE ACS were established. In patients of all groups the dynamics of BPs and BPd was recorded, indicators stabilized central hemodynamics. By reducing the degree of ecoendotoxicosis, EDV and ESV, LCDI, LV systolic function improves, EF increases (group 1-2). However, in the first and third groups, single ventricular extrasystoles were recorded in one patient. AHF was recorded in one patient In patients of 1st group. In the PCI-only group, 2 patients developed recurrent NT ACS, 3 had restenosis, 3 had AHF, and 2 patients died. The results of this study show that the complex use of drug therapy with PCI allows to get a prognostically positive result, in contrast to a separate PCI therapy.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - The Effect of the Combined Use of Mechanical and Drug Revascularization in Acute Coronary Syndrome in Patients Working in Environmentally Polluted Conditions
AU  - Tarana Mammadhasan Javadova
AU  - Mammadhasan Mammadhuseyn Agayev
Y1  - 2022/09/14
PY  - 2022
N1  - https://doi.org/10.11648/j.ajcem.20221005.11
DO  - 10.11648/j.ajcem.20221005.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 107
EP  - 114
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20221005.11
AB  - The aim of the study was to evaluate the effect of the complex use of cardiotex (meldonium), obzidan (propranolol), cyto-mac, cardiket, preductal OD, ARBII, in combination with percutaneous intervention (PCI) and separately performed PCI on ecoendotoxicosis (AMP), on hemodynamics, cardiodynamics and clinical course of non-ST elevation acute coronary syndrome (NSTE ACS). The results of complex medical and mechanical revascularization and separately performed PCI were compared. The study included 63 patients with NSTE ACS aged 35 to 65 years (56.7 ± 1.20) (50 (79.4%) men, 13 (20.6%) women) and randomized into 3 groups (21 people each). 1st group got cardiotex, cyto-mac, obzidan (propranolol) were given anti-ischemic, isosorbidedinitrate (cardiket), antihypoxant - a biologically active food supplement vascard and PCI was performed. In group 2, cytomac and obzidan (propranolol), cardiotex were administered, anti-ischemic, antihypoxant –vascard, preductal OD, ARBII - losartan were given and PCI was performed a day later; in the 3rd group, only PCI was performed. All patients got heparin according to the schemes. During hospitalization and within a year after discharge drug therapy was carried out, including aspirin-cardio+clopidogril. At the same time, 2 times a year for 3 months, one capsule of vascard was taken once a day, one tablet of preductal OD once a day+losartan 12.5 (25) mg once a day, cardiotex was administered intravenously at 500 mg once per day for 15 days. In all groups, the degree of ecoendotoxicosis was determined in the blood, using echocardiography and Doppler echocardiography, the values of end systolic (ESV) and end diastolic (EDV) volumes, ejection fraction (EF), stroke index (SI), cardiac index (CI), local contractility disorder index (LCDI) of the left ventricle, restenosis-with the help of repeated coronary angiography, ECG for ST-segment elevation and repeated anginal pain. The dynamics of BPs and BPd and the clinical course of NSTE ACS were established. In patients of all groups the dynamics of BPs and BPd was recorded, indicators stabilized central hemodynamics. By reducing the degree of ecoendotoxicosis, EDV and ESV, LCDI, LV systolic function improves, EF increases (group 1-2). However, in the first and third groups, single ventricular extrasystoles were recorded in one patient. AHF was recorded in one patient In patients of 1st group. In the PCI-only group, 2 patients developed recurrent NT ACS, 3 had restenosis, 3 had AHF, and 2 patients died. The results of this study show that the complex use of drug therapy with PCI allows to get a prognostically positive result, in contrast to a separate PCI therapy.
VL  - 10
IS  - 5
ER  -

Copy | Download

Author Information

Tarana Mammadhasan Javadova

The Scientific Research Institute of Cardiology Named After Academic J. Abdullayev, Baku, Azerbaijan
Mammadhasan Mammadhuseyn Agayev

Internal Medicine №2, Azerbaijan Medical University, Baku, Azerbaijan

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Tarana Mammadhasan Javadova, Mammadhasan Mammadhuseyn Agayev. (2022). The Effect of the Combined Use of Mechanical and Drug Revascularization in Acute Coronary Syndrome in Patients Working in Environmentally Polluted Conditions. American Journal of Clinical and Experimental Medicine, 10(5), 107-114. https://doi.org/10.11648/j.ajcem.20221005.11

Copy | Download

ACS Style

Tarana Mammadhasan Javadova; Mammadhasan Mammadhuseyn Agayev. The Effect of the Combined Use of Mechanical and Drug Revascularization in Acute Coronary Syndrome in Patients Working in Environmentally Polluted Conditions. Am. J. Clin. Exp. Med. 2022, 10(5), 107-114. doi: 10.11648/j.ajcem.20221005.11

Copy | Download

AMA Style

Tarana Mammadhasan Javadova, Mammadhasan Mammadhuseyn Agayev. The Effect of the Combined Use of Mechanical and Drug Revascularization in Acute Coronary Syndrome in Patients Working in Environmentally Polluted Conditions. Am J Clin Exp Med. 2022;10(5):107-114. doi: 10.11648/j.ajcem.20221005.11

Copy | Download

@article{10.11648/j.ajcem.20221005.11,
  author = {Tarana Mammadhasan Javadova and Mammadhasan Mammadhuseyn Agayev},
  title = {The Effect of the Combined Use of Mechanical and Drug Revascularization in Acute Coronary Syndrome in Patients Working in Environmentally Polluted Conditions},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {10},
  number = {5},
  pages = {107-114},
  doi = {10.11648/j.ajcem.20221005.11},
  url = {https://doi.org/10.11648/j.ajcem.20221005.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20221005.11},
  abstract = {The aim of the study was to evaluate the effect of the complex use of cardiotex (meldonium), obzidan (propranolol), cyto-mac, cardiket, preductal OD, ARBII, in combination with percutaneous intervention (PCI) and separately performed PCI on ecoendotoxicosis (AMP), on hemodynamics, cardiodynamics and clinical course of non-ST elevation acute coronary syndrome (NSTE ACS). The results of complex medical and mechanical revascularization and separately performed PCI were compared. The study included 63 patients with NSTE ACS aged 35 to 65 years (56.7 ± 1.20) (50 (79.4%) men, 13 (20.6%) women) and randomized into 3 groups (21 people each). 1st group got cardiotex, cyto-mac, obzidan (propranolol) were given anti-ischemic, isosorbidedinitrate (cardiket), antihypoxant - a biologically active food supplement vascard and PCI was performed. In group 2, cytomac and obzidan (propranolol), cardiotex were administered, anti-ischemic, antihypoxant –vascard, preductal OD, ARBII - losartan were given and PCI was performed a day later; in the 3rd group, only PCI was performed. All patients got heparin according to the schemes. During hospitalization and within a year after discharge drug therapy was carried out, including aspirin-cardio+clopidogril. At the same time, 2 times a year for 3 months, one capsule of vascard was taken once a day, one tablet of preductal OD once a day+losartan 12.5 (25) mg once a day, cardiotex was administered intravenously at 500 mg once per day for 15 days. In all groups, the degree of ecoendotoxicosis was determined in the blood, using echocardiography and Doppler echocardiography, the values of end systolic (ESV) and end diastolic (EDV) volumes, ejection fraction (EF), stroke index (SI), cardiac index (CI), local contractility disorder index (LCDI) of the left ventricle, restenosis-with the help of repeated coronary angiography, ECG for ST-segment elevation and repeated anginal pain. The dynamics of BPs and BPd and the clinical course of NSTE ACS were established. In patients of all groups the dynamics of BPs and BPd was recorded, indicators stabilized central hemodynamics. By reducing the degree of ecoendotoxicosis, EDV and ESV, LCDI, LV systolic function improves, EF increases (group 1-2). However, in the first and third groups, single ventricular extrasystoles were recorded in one patient. AHF was recorded in one patient In patients of 1st group. In the PCI-only group, 2 patients developed recurrent NT ACS, 3 had restenosis, 3 had AHF, and 2 patients died. The results of this study show that the complex use of drug therapy with PCI allows to get a prognostically positive result, in contrast to a separate PCI therapy.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - The Effect of the Combined Use of Mechanical and Drug Revascularization in Acute Coronary Syndrome in Patients Working in Environmentally Polluted Conditions
AU  - Tarana Mammadhasan Javadova
AU  - Mammadhasan Mammadhuseyn Agayev
Y1  - 2022/09/14
PY  - 2022
N1  - https://doi.org/10.11648/j.ajcem.20221005.11
DO  - 10.11648/j.ajcem.20221005.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 107
EP  - 114
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20221005.11
AB  - The aim of the study was to evaluate the effect of the complex use of cardiotex (meldonium), obzidan (propranolol), cyto-mac, cardiket, preductal OD, ARBII, in combination with percutaneous intervention (PCI) and separately performed PCI on ecoendotoxicosis (AMP), on hemodynamics, cardiodynamics and clinical course of non-ST elevation acute coronary syndrome (NSTE ACS). The results of complex medical and mechanical revascularization and separately performed PCI were compared. The study included 63 patients with NSTE ACS aged 35 to 65 years (56.7 ± 1.20) (50 (79.4%) men, 13 (20.6%) women) and randomized into 3 groups (21 people each). 1st group got cardiotex, cyto-mac, obzidan (propranolol) were given anti-ischemic, isosorbidedinitrate (cardiket), antihypoxant - a biologically active food supplement vascard and PCI was performed. In group 2, cytomac and obzidan (propranolol), cardiotex were administered, anti-ischemic, antihypoxant –vascard, preductal OD, ARBII - losartan were given and PCI was performed a day later; in the 3rd group, only PCI was performed. All patients got heparin according to the schemes. During hospitalization and within a year after discharge drug therapy was carried out, including aspirin-cardio+clopidogril. At the same time, 2 times a year for 3 months, one capsule of vascard was taken once a day, one tablet of preductal OD once a day+losartan 12.5 (25) mg once a day, cardiotex was administered intravenously at 500 mg once per day for 15 days. In all groups, the degree of ecoendotoxicosis was determined in the blood, using echocardiography and Doppler echocardiography, the values of end systolic (ESV) and end diastolic (EDV) volumes, ejection fraction (EF), stroke index (SI), cardiac index (CI), local contractility disorder index (LCDI) of the left ventricle, restenosis-with the help of repeated coronary angiography, ECG for ST-segment elevation and repeated anginal pain. The dynamics of BPs and BPd and the clinical course of NSTE ACS were established. In patients of all groups the dynamics of BPs and BPd was recorded, indicators stabilized central hemodynamics. By reducing the degree of ecoendotoxicosis, EDV and ESV, LCDI, LV systolic function improves, EF increases (group 1-2). However, in the first and third groups, single ventricular extrasystoles were recorded in one patient. AHF was recorded in one patient In patients of 1st group. In the PCI-only group, 2 patients developed recurrent NT ACS, 3 had restenosis, 3 had AHF, and 2 patients died. The results of this study show that the complex use of drug therapy with PCI allows to get a prognostically positive result, in contrast to a separate PCI therapy.
VL  - 10
IS  - 5
ER  -

Copy | Download