Objectives: The morbidity rate of hypothyroidism is relatively high, the features of which are delitescent invasion, long course, untypical symptoms, great harm, etc. To intervene and cure hypothyroidism by traditional Chinese medicine could palliate untoward reaction of Western medicine, relieve symptoms of patients and enhance immunity. Astragalus mongholicus is frequently used as clinical traditional Chinese medicine. Reported by some literatures, compositions of Astragalus mongholicus have antioxidative function. Therefore, we studied effects of Astragalus mongholicus and its fermentation objects on anti-oxidation capability of hypothyroidism rats, and then discussed its mechanism of action. Methods: Eighty Wistar rats, half of which are female, were randomly divided into eight groups. They were named normal control group, hypothyroidism model group, high-dose Astragalus mongholicus group, medium-dose Astragalus mongholicus group, low-dose Astragalus mongholicus group, high-dose Astragalus mongholicus fermentation objects group, medium-dose Astragalus mongholicus fermentation objects group, low-dose Astragalus mongholicus fermentation objects group. There were ten rats in each group. We copied hypothyroidism rats samples by chemical induction------0.05% PTU freely drinking water. The rats were treated by different doses of Astragalus mongholicus as well as its, fermentation objects and killed after four weeks. We tested activity of serum superoxide dismutases (SOD), glutathion peroxidase (GSH-Px) nitricoxide synthase (NOS); contents of malondialdehyde (MDA), nitrogen monoxidum (NO) and the function of glandula thyreoidea. Results: After being treated by Astragalus mongholicus as well as its fermentation objects, the hypothyroidism rats’ function of glandula thyreoidea has improved evidently (P<0.05). Secondly, contents of malondialdehyde (MDA) in blood serum degraded remarkably (P<0.05). Thirdly, activity of superoxide dismutases (SOD) and glutathione. Peroxidase (GSH-Px) in blood serum stepped up strikingly (P<0.05). Fourthly, vis vitalis of nitric oxide synthase (NOS) and contents of nitrogen monoxidum (NO) in blood serum stepped down surprisingly (P<0.05). Conclusion: Astragalus mongholicus and its fermentation objects have certain therapeutical effects on thyroid hypofunction, whose mechanism has something to do with increasing anti-oxidation capability of hypothyroidism rats.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 9, Issue 6) |
| DOI | 10.11648/j.ajcem.20210906.14 |
| Page(s) | 209-214 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Astragalus Mongholicus and Its Fermentation Objects, Hypothyroidism Rats, Anti-oxidation Capability
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APA Style
Yang Xiaohui, Li Chao, Zhang Jingjing, Yu Yongjun, Li Rongyao, et al. (2021). Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats. American Journal of Clinical and Experimental Medicine, 9(6), 209-214. https://doi.org/10.11648/j.ajcem.20210906.14
ACS Style
Yang Xiaohui; Li Chao; Zhang Jingjing; Yu Yongjun; Li Rongyao, et al. Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats. Am. J. Clin. Exp. Med. 2021, 9(6), 209-214. doi: 10.11648/j.ajcem.20210906.14
AMA Style
Yang Xiaohui, Li Chao, Zhang Jingjing, Yu Yongjun, Li Rongyao, et al. Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats. Am J Clin Exp Med. 2021;9(6):209-214. doi: 10.11648/j.ajcem.20210906.14
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Download@article{10.11648/j.ajcem.20210906.14,
author = {Yang Xiaohui and Li Chao and Zhang Jingjing and Yu Yongjun and Li Rongyao and Liu Chao and Hou Zhenjiang},
title = {Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {9},
number = {6},
pages = {209-214},
doi = {10.11648/j.ajcem.20210906.14},
url = {https://doi.org/10.11648/j.ajcem.20210906.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210906.14},
abstract = {Objectives: The morbidity rate of hypothyroidism is relatively high, the features of which are delitescent invasion, long course, untypical symptoms, great harm, etc. To intervene and cure hypothyroidism by traditional Chinese medicine could palliate untoward reaction of Western medicine, relieve symptoms of patients and enhance immunity. Astragalus mongholicus is frequently used as clinical traditional Chinese medicine. Reported by some literatures, compositions of Astragalus mongholicus have antioxidative function. Therefore, we studied effects of Astragalus mongholicus and its fermentation objects on anti-oxidation capability of hypothyroidism rats, and then discussed its mechanism of action. Methods: Eighty Wistar rats, half of which are female, were randomly divided into eight groups. They were named normal control group, hypothyroidism model group, high-dose Astragalus mongholicus group, medium-dose Astragalus mongholicus group, low-dose Astragalus mongholicus group, high-dose Astragalus mongholicus fermentation objects group, medium-dose Astragalus mongholicus fermentation objects group, low-dose Astragalus mongholicus fermentation objects group. There were ten rats in each group. We copied hypothyroidism rats samples by chemical induction------0.05% PTU freely drinking water. The rats were treated by different doses of Astragalus mongholicus as well as its, fermentation objects and killed after four weeks. We tested activity of serum superoxide dismutases (SOD), glutathion peroxidase (GSH-Px) nitricoxide synthase (NOS); contents of malondialdehyde (MDA), nitrogen monoxidum (NO) and the function of glandula thyreoidea. Results: After being treated by Astragalus mongholicus as well as its fermentation objects, the hypothyroidism rats’ function of glandula thyreoidea has improved evidently (PConclusion: Astragalus mongholicus and its fermentation objects have certain therapeutical effects on thyroid hypofunction, whose mechanism has something to do with increasing anti-oxidation capability of hypothyroidism rats.},
year = {2021}
}
TY - JOUR T1 - Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats AU - Yang Xiaohui AU - Li Chao AU - Zhang Jingjing AU - Yu Yongjun AU - Li Rongyao AU - Liu Chao AU - Hou Zhenjiang Y1 - 2021/12/07 PY - 2021 N1 - https://doi.org/10.11648/j.ajcem.20210906.14 DO - 10.11648/j.ajcem.20210906.14 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 209 EP - 214 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20210906.14 AB - Objectives: The morbidity rate of hypothyroidism is relatively high, the features of which are delitescent invasion, long course, untypical symptoms, great harm, etc. To intervene and cure hypothyroidism by traditional Chinese medicine could palliate untoward reaction of Western medicine, relieve symptoms of patients and enhance immunity. Astragalus mongholicus is frequently used as clinical traditional Chinese medicine. Reported by some literatures, compositions of Astragalus mongholicus have antioxidative function. Therefore, we studied effects of Astragalus mongholicus and its fermentation objects on anti-oxidation capability of hypothyroidism rats, and then discussed its mechanism of action. Methods: Eighty Wistar rats, half of which are female, were randomly divided into eight groups. They were named normal control group, hypothyroidism model group, high-dose Astragalus mongholicus group, medium-dose Astragalus mongholicus group, low-dose Astragalus mongholicus group, high-dose Astragalus mongholicus fermentation objects group, medium-dose Astragalus mongholicus fermentation objects group, low-dose Astragalus mongholicus fermentation objects group. There were ten rats in each group. We copied hypothyroidism rats samples by chemical induction------0.05% PTU freely drinking water. The rats were treated by different doses of Astragalus mongholicus as well as its, fermentation objects and killed after four weeks. We tested activity of serum superoxide dismutases (SOD), glutathion peroxidase (GSH-Px) nitricoxide synthase (NOS); contents of malondialdehyde (MDA), nitrogen monoxidum (NO) and the function of glandula thyreoidea. Results: After being treated by Astragalus mongholicus as well as its fermentation objects, the hypothyroidism rats’ function of glandula thyreoidea has improved evidently (PConclusion: Astragalus mongholicus and its fermentation objects have certain therapeutical effects on thyroid hypofunction, whose mechanism has something to do with increasing anti-oxidation capability of hypothyroidism rats. VL - 9 IS - 6 ER -
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