A Novel Approach to Treatment of Pinguecula Using Atmospheric Low-temperature Plasma: A Clinical Case Series

Farhad Nejat; Khosrow Jadidi; Mohammad Amin Nejat; Nazanin-Sadat Nabavi; Seyede-Yasamin Adnani; Shima Eghtedari

doi:doi:10.11648/j.ajcem.20210905.13

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A Novel Approach to Treatment of Pinguecula Using Atmospheric Low-temperature Plasma: A Clinical Case Series

Farhad Nejat, Khosrow Jadidi, Mohammad Amin Nejat, Nazanin-Sadat Nabavi, Seyede-Yasamin Adnani, Shima Eghtedari

Published in American Journal of Clinical and Experimental Medicine (Volume 9, Issue 5)

Received: 26 August 2021 Accepted: 13 September 2021 Published: 30 September 2021

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Abstract

Background: In recent years plasma medicine, played an important role in treating several ocular surface disorders. This study will introduce atmospheric low-temperature plasma (ALTP) for removing the pinguecula. Methods: In the clinical case series, five eyes of five patients (2 patients OD, 3 patients OS) with pinguecula were included. The pinguecula removed and completely healed, using the white handpiece of the plasma generator device (Plexr, GMV s.r.l Grottaferrata, Italy). Refraction parameters, uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (BDVA), intraocular pressure (IOP), corneal fluorescein staining (CFS), contrast sensitivity (CS) and dry eye tests including, tear meniscus height (TMH) and tear breakup time (TBUT) were measured before, one month and six months after treatment for all patients. Results: The median size of the pinguecula was 3.5 mm (ranged from 2.5 to 4.5 mm). In all patients, the pinguecula was completely sublimated and after six months of follow-up, no evidence of recurrence was observed. In addition, the patient follow-up did not reveal any considerable complications during or 6 months after the surgery. Conclusion: Overall, the current study showed that, plasma assisted noninvasive surgery (PANIS method) is a simple, office-based, minimally invasive, effective approach to treat pinguecula with no considerable complications but it is noteworthy that, study with higher sample size like clinical trial is needed.

Published in	American Journal of Clinical and Experimental Medicine (Volume 9, Issue 5)
DOI	10.11648/j.ajcem.20210905.13
Page(s)	142-146
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Pinguecula, Sublimation, Soft Surgery, PANIS Method, Atmospheric Low-temperature Plasma

References

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[2]	Mimura, T., et al., Severity and determinants of pinguecula in a hospital-based population. Eye & Contact Lens, 2011. 37 (1): p. 31-35.
[3]	Frucht-Pery, J., et al., Treatment of inflamed pterygium and pinguecula with topical indomethacin 0.1% solution. Cornea, 1997. 16 (1): p. 42-47.
[4]	Mimura, T., et al., Pinguecula and contact lenses. Eye, 2010. 24 (11): p. 1685-1691.
[5]	Jeong, J., et al., The Improvement of Dry Eye Symptoms after Pinguecula Excision and Conjunctival Autograft with Fibrin Glue. Journal of ophthalmology, 2019. 2019.
[6]	Panchapakesan, J., F. Hourihan, and P. Mitchell, Prevalence of pterygium and pinguecula: the Blue Mountains Eye Study. Australian and New Zealand journal of ophthalmology, 1998. 26: p. S2-S5.
[7]	Fotouhi, A., et al., Prevalence and risk factors of pterygium and pinguecula: the Tehran Eye Study. Eye, 2009. 23 (5): p. 1125-1129.
[8]	Rezvan, F., et al., The prevalence and determinants of pterygium and pinguecula in an urban population in Shahroud, Iran. Acta Medica Iranica, 2012: p. 689-696.
[9]	Ahn, S. J., et al., One-year outcome of argon laser photocoagulation of pinguecula. Cornea, 2013. 32 (7): p. 971-975.
[10]	Jung, S., et al., Vascular regression after pinguecula excision and conjunctival autograft using fibrin glue. Eye & contact lens, 2017. 43 (3): p. 199-202.
[11]	Laroussi, M., Plasma medicine: a brief introduction. Plasma, 2018. 1 (1): p. 47-60.
[12]	Claiborne, D., et al., Low-temperature atmospheric pressure plasma enhanced tooth whitening: The next-generation technology. International Journal of Dental Hygiene, 2014. 12 (2): p. 108-114.
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[14]	Zimmermann, J. L., et al., Disinfection Through Different Textiles Using Low-temperature Atmospheric Pressure Plasma. Plasma Processes and Polymers, 2012. 9 (8): p. 792-798.
[15]	Nejat, F., et al., Safety evaluation of the plasma on ocular surface tissue: An animal study and histopathological findings. Clinical Plasma Medicine, 2019. 14: p. 100084.
[16]	Schiffman, R. M., et al., Reliability and validity of the ocular surface disease index. Archives of ophthalmology, 2000. 118 (5): p. 615-621.
[17]	Bell, A., Pinguecula. Journal of Visual Communication in Medicine, 2006. 29 (2): p. 82-83.
[18]	Arenas-Archila, E., K. Arellano, and D. Muñoz-Sarmiento, Intra-lesional injection of betamethasone for the treatment of symptomatic pinguecula. Archivos de la Sociedad Española de Oftalmología (English Edition), 2014. 89 (10): p. 408-410.
[19]	Somnath, A. and K. Tripathy, Pinguecula. StatPearls [Internet], 2020.

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Farhad Nejat, Khosrow Jadidi, Mohammad Amin Nejat, Nazanin-Sadat Nabavi, Seyede-Yasamin Adnani, et al. (2021). A Novel Approach to Treatment of Pinguecula Using Atmospheric Low-temperature Plasma: A Clinical Case Series. American Journal of Clinical and Experimental Medicine, 9(5), 142-146. https://doi.org/10.11648/j.ajcem.20210905.13

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ACS Style

Farhad Nejat; Khosrow Jadidi; Mohammad Amin Nejat; Nazanin-Sadat Nabavi; Seyede-Yasamin Adnani, et al. A Novel Approach to Treatment of Pinguecula Using Atmospheric Low-temperature Plasma: A Clinical Case Series. Am. J. Clin. Exp. Med. 2021, 9(5), 142-146. doi: 10.11648/j.ajcem.20210905.13

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AMA Style

Farhad Nejat, Khosrow Jadidi, Mohammad Amin Nejat, Nazanin-Sadat Nabavi, Seyede-Yasamin Adnani, et al. A Novel Approach to Treatment of Pinguecula Using Atmospheric Low-temperature Plasma: A Clinical Case Series. Am J Clin Exp Med. 2021;9(5):142-146. doi: 10.11648/j.ajcem.20210905.13

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@article{10.11648/j.ajcem.20210905.13,
  author = {Farhad Nejat and Khosrow Jadidi and Mohammad Amin Nejat and Nazanin-Sadat Nabavi and Seyede-Yasamin Adnani and Shima Eghtedari},
  title = {A Novel Approach to Treatment of Pinguecula Using Atmospheric Low-temperature Plasma: A Clinical Case Series},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {9},
  number = {5},
  pages = {142-146},
  doi = {10.11648/j.ajcem.20210905.13},
  url = {https://doi.org/10.11648/j.ajcem.20210905.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210905.13},
  abstract = {Background: In recent years plasma medicine, played an important role in treating several ocular surface disorders. This study will introduce atmospheric low-temperature plasma (ALTP) for removing the pinguecula. Methods: In the clinical case series, five eyes of five patients (2 patients OD, 3 patients OS) with pinguecula were included. The pinguecula removed and completely healed, using the white handpiece of the plasma generator device (Plexr, GMV s.r.l Grottaferrata, Italy). Refraction parameters, uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (BDVA), intraocular pressure (IOP), corneal fluorescein staining (CFS), contrast sensitivity (CS) and dry eye tests including, tear meniscus height (TMH) and tear breakup time (TBUT) were measured before, one month and six months after treatment for all patients. Results: The median size of the pinguecula was 3.5 mm (ranged from 2.5 to 4.5 mm). In all patients, the pinguecula was completely sublimated and after six months of follow-up, no evidence of recurrence was observed. In addition, the patient follow-up did not reveal any considerable complications during or 6 months after the surgery. Conclusion: Overall, the current study showed that, plasma assisted noninvasive surgery (PANIS method) is a simple, office-based, minimally invasive, effective approach to treat pinguecula with no considerable complications but it is noteworthy that, study with higher sample size like clinical trial is needed.},
 year = {2021}
}

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TY  - JOUR
T1  - A Novel Approach to Treatment of Pinguecula Using Atmospheric Low-temperature Plasma: A Clinical Case Series
AU  - Farhad Nejat
AU  - Khosrow Jadidi
AU  - Mohammad Amin Nejat
AU  - Nazanin-Sadat Nabavi
AU  - Seyede-Yasamin Adnani
AU  - Shima Eghtedari
Y1  - 2021/09/30
PY  - 2021
N1  - https://doi.org/10.11648/j.ajcem.20210905.13
DO  - 10.11648/j.ajcem.20210905.13
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 142
EP  - 146
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20210905.13
AB  - Background: In recent years plasma medicine, played an important role in treating several ocular surface disorders. This study will introduce atmospheric low-temperature plasma (ALTP) for removing the pinguecula. Methods: In the clinical case series, five eyes of five patients (2 patients OD, 3 patients OS) with pinguecula were included. The pinguecula removed and completely healed, using the white handpiece of the plasma generator device (Plexr, GMV s.r.l Grottaferrata, Italy). Refraction parameters, uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (BDVA), intraocular pressure (IOP), corneal fluorescein staining (CFS), contrast sensitivity (CS) and dry eye tests including, tear meniscus height (TMH) and tear breakup time (TBUT) were measured before, one month and six months after treatment for all patients. Results: The median size of the pinguecula was 3.5 mm (ranged from 2.5 to 4.5 mm). In all patients, the pinguecula was completely sublimated and after six months of follow-up, no evidence of recurrence was observed. In addition, the patient follow-up did not reveal any considerable complications during or 6 months after the surgery. Conclusion: Overall, the current study showed that, plasma assisted noninvasive surgery (PANIS method) is a simple, office-based, minimally invasive, effective approach to treat pinguecula with no considerable complications but it is noteworthy that, study with higher sample size like clinical trial is needed.
VL  - 9
IS  - 5
ER  -

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Author Information

Farhad Nejat

Vision Health Research Center, Semnan University of Medical Sciences, Semnan, Iran
Khosrow Jadidi

Vision Health Research Center, Semnan University of Medical Sciences, Semnan, Iran
Mohammad Amin Nejat

Vision Health Research Center, Semnan University of Medical Sciences, Semnan, Iran
Nazanin-Sadat Nabavi

Vision Health Research Center, Semnan University of Medical Sciences, Semnan, Iran
Seyede-Yasamin Adnani

Vision Health Research Center, Semnan University of Medical Sciences, Semnan, Iran
Shima Eghtedari

Vision Health Research Center, Semnan University of Medical Sciences, Semnan, Iran

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APA Style

Farhad Nejat, Khosrow Jadidi, Mohammad Amin Nejat, Nazanin-Sadat Nabavi, Seyede-Yasamin Adnani, et al. (2021). A Novel Approach to Treatment of Pinguecula Using Atmospheric Low-temperature Plasma: A Clinical Case Series. American Journal of Clinical and Experimental Medicine, 9(5), 142-146. https://doi.org/10.11648/j.ajcem.20210905.13

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ACS Style

Farhad Nejat; Khosrow Jadidi; Mohammad Amin Nejat; Nazanin-Sadat Nabavi; Seyede-Yasamin Adnani, et al. A Novel Approach to Treatment of Pinguecula Using Atmospheric Low-temperature Plasma: A Clinical Case Series. Am. J. Clin. Exp. Med. 2021, 9(5), 142-146. doi: 10.11648/j.ajcem.20210905.13

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AMA Style

Farhad Nejat, Khosrow Jadidi, Mohammad Amin Nejat, Nazanin-Sadat Nabavi, Seyede-Yasamin Adnani, et al. A Novel Approach to Treatment of Pinguecula Using Atmospheric Low-temperature Plasma: A Clinical Case Series. Am J Clin Exp Med. 2021;9(5):142-146. doi: 10.11648/j.ajcem.20210905.13

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@article{10.11648/j.ajcem.20210905.13,
  author = {Farhad Nejat and Khosrow Jadidi and Mohammad Amin Nejat and Nazanin-Sadat Nabavi and Seyede-Yasamin Adnani and Shima Eghtedari},
  title = {A Novel Approach to Treatment of Pinguecula Using Atmospheric Low-temperature Plasma: A Clinical Case Series},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {9},
  number = {5},
  pages = {142-146},
  doi = {10.11648/j.ajcem.20210905.13},
  url = {https://doi.org/10.11648/j.ajcem.20210905.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210905.13},
  abstract = {Background: In recent years plasma medicine, played an important role in treating several ocular surface disorders. This study will introduce atmospheric low-temperature plasma (ALTP) for removing the pinguecula. Methods: In the clinical case series, five eyes of five patients (2 patients OD, 3 patients OS) with pinguecula were included. The pinguecula removed and completely healed, using the white handpiece of the plasma generator device (Plexr, GMV s.r.l Grottaferrata, Italy). Refraction parameters, uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (BDVA), intraocular pressure (IOP), corneal fluorescein staining (CFS), contrast sensitivity (CS) and dry eye tests including, tear meniscus height (TMH) and tear breakup time (TBUT) were measured before, one month and six months after treatment for all patients. Results: The median size of the pinguecula was 3.5 mm (ranged from 2.5 to 4.5 mm). In all patients, the pinguecula was completely sublimated and after six months of follow-up, no evidence of recurrence was observed. In addition, the patient follow-up did not reveal any considerable complications during or 6 months after the surgery. Conclusion: Overall, the current study showed that, plasma assisted noninvasive surgery (PANIS method) is a simple, office-based, minimally invasive, effective approach to treat pinguecula with no considerable complications but it is noteworthy that, study with higher sample size like clinical trial is needed.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - A Novel Approach to Treatment of Pinguecula Using Atmospheric Low-temperature Plasma: A Clinical Case Series
AU  - Farhad Nejat
AU  - Khosrow Jadidi
AU  - Mohammad Amin Nejat
AU  - Nazanin-Sadat Nabavi
AU  - Seyede-Yasamin Adnani
AU  - Shima Eghtedari
Y1  - 2021/09/30
PY  - 2021
N1  - https://doi.org/10.11648/j.ajcem.20210905.13
DO  - 10.11648/j.ajcem.20210905.13
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 142
EP  - 146
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20210905.13
AB  - Background: In recent years plasma medicine, played an important role in treating several ocular surface disorders. This study will introduce atmospheric low-temperature plasma (ALTP) for removing the pinguecula. Methods: In the clinical case series, five eyes of five patients (2 patients OD, 3 patients OS) with pinguecula were included. The pinguecula removed and completely healed, using the white handpiece of the plasma generator device (Plexr, GMV s.r.l Grottaferrata, Italy). Refraction parameters, uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (BDVA), intraocular pressure (IOP), corneal fluorescein staining (CFS), contrast sensitivity (CS) and dry eye tests including, tear meniscus height (TMH) and tear breakup time (TBUT) were measured before, one month and six months after treatment for all patients. Results: The median size of the pinguecula was 3.5 mm (ranged from 2.5 to 4.5 mm). In all patients, the pinguecula was completely sublimated and after six months of follow-up, no evidence of recurrence was observed. In addition, the patient follow-up did not reveal any considerable complications during or 6 months after the surgery. Conclusion: Overall, the current study showed that, plasma assisted noninvasive surgery (PANIS method) is a simple, office-based, minimally invasive, effective approach to treat pinguecula with no considerable complications but it is noteworthy that, study with higher sample size like clinical trial is needed.
VL  - 9
IS  - 5
ER  -

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