Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology

Hou Jianzhang; Li Yong

doi:doi:10.11648/j.ajcem.20210903.12

| Peer-Reviewed

Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology

Hou Jianzhang, Li Yong

Published in American Journal of Clinical and Experimental Medicine (Volume 9, Issue 3)

Received: 20 April 2021 Accepted: Published: 24 May 2021

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Purpose: Discuss the diagnosis value and action mechanism of S100P for gastric cancer and the influence of S100P in tumor metastasis. Method: Collect 100 cases of gastric cancer tissues diagnosed as per histopathology by our hospital, apply immunohistochemistry method, test the positive expression condition of S100P protein, compare with 100 cases of control tissue specimens, and analyze the relationship between S100 protein expression condition in gastric cancer tissue and clinical pathology. Result: the positive rate (51.0%) of S100P in gastric cancer tissue is significantly lower than chronic atrophic gastritis with atypical hyperplasia, superficial gastritis and normal gastric mucosa (P<0.001 or P<0.05), while the difference between gastric cancer group and group of chronic atrophic gastritis with atypical hyperplasia has no statistic significance (P>0.05). The difference of positive rate of S100P in gastric cancer tissue with gender, age, tumor size, tumor position and Lauren typing has no statistic significance. In well differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated adenocarcinoma and adenocarcinoma anaplastic, the positive rate (80.56%) of S100P of the three groups has significant difference (χ²=13.912, P=0.001). The positive rate of S100P which doesn’t invade serosa is significantly higher than the positive rate (34.38%, χ²=19.662, P<0.001) of S100P invading serosa and invading beyond the serosa, and the difference of positive rate of S100P of Phase I, Phase II, Phase III and Phase IV also has statistic difference (χ²=13.347, P=0.004), the positive rate (73.17%) of localized S100P protein is significantly higher than the positive rate (35.59%, χ²=13.669, P<0.001) of invasive type; the positive rate (74.42%) of S100P without lymph node metastasis is significantly higher than the positive rate (33.33%, χ²=15.020, P<0.001) with lymph node metastasis. Conclusion: the positive rate of S100P protein in gastric cancer tissue is significantly lower than the para-carcinoma tissue; the lower the differentiation degree is, the deeper the invasion is; the patients who have later TNM staging and Borrmanntyping, and lymph node metastasis have lower positive rate of S100P protein, which indicates that the low expression of S100P protein participates in the occurrence, development, invasion and metastasis of gastric cancer, and is an independent dangerous factor affecting the patients’ prognosis.

Published in	American Journal of Clinical and Experimental Medicine (Volume 9, Issue 3)
DOI	10.11648/j.ajcem.20210903.12
Page(s)	55-64
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Gastric Cancer, S100P, Degree of Differentiation, Borrmann Classification, TNM Staging, Lymph Node Metastasis

References

[1]	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence andmortalityworldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin, 2018, 68 (6): 394-424.
[2]	Zhou JS, Zheng RS, Zhuang GH, et al. Analysis on the trend of gastric cancer incidence and age change in cancer registration regions of China [J]. J Applied Oncology 2000 to 2015 [J]. 2020, 34 (1): 1-5.
[3]	Song ZH, Xu XN, Li KL, et al., Research progress on etiology of gastric cancer [J]. Chin Med J Metall Indus, 2020, 37 (5): 509-511.
[4]	Li SS, Xu H, Han XC. Research progress of S100P-a new member ofthe S100 family and its relationship with tumor [J]. Chin Med Herald, 2015, 12 (12): 45-49.
[5]	Wang G, Platt-Higgins A, Carroll J, et al. Induction of metastasis by S100P in a rat mammary model and its association with poor survival of breast cancer patients [J]. Cancer Res, 2006, 66 (2): 1199-1207.
[6]	Surowiak P, Maciejczyk A, Materna V, et al. Unfavourable prognostic significance of S100P expression in ovarian cancers [J]. Histopathology. 2007, 51 (1): 125-128.
[7]	Hou JZ, Li Y. Research Development of Calcium-Binding Protein S100P in Digestive Tumor [J]. Med Recap, 2017, 23 (19): 3796-3800.
[8]	Ministry of Health of the People's Republic of China. Standard practice for diagnosis and treatment of Gastric Cancer (2011 edition) [J]. Chinese Journal of Medical Frontier (electronic version) 2012, 4 (5): 62-71.
[9]	Song J, Dong SL, Duan JP, et al. Expression of SDF-1/CXCR4 in gastriccarcinoma of different Borrmanntype and its cli-nical significances [J]. Chin J Clinicians (Electronic Edition), 2015, 9 (20): 3691-3695.
[10]	M. B. Aminetal. American Joint Committee on Cáncer A JCC Cáncer Staging M anual, Eighth Edition [J]. 2017, 203-220.
[11]	Feng RM, Zong YN, Cao SM, et al. Current cancer situation in China: Good or bad news from the 2018 Global Cancer Statistics? [J]. Cancer Commun (Lond). 2019. 39 (1): 22.
[12]	Wang SM, Zheng RS, Zhang SW, et al. Epidemiological characteristics of gastric cancer in China, 2015 [J]. Chin J Epidemiol. 2019, 40 (12): 1517-1521.
[13]	Wang YK, Li ZY, Shan F, et al. Current status of diagnosis and treatment of early gastric cancer in China-Data from China Gastrointestinal Cancer Surgery Union Chin J Gastrointest Sur, 2018, 21 (2): 169-174.
[14]	Niu Y, Shao Z, Wang H, et al. LASP1-S100A11 axis promotes colorectal cancer aggressiveness by modulating TGFβ/Smad signaling [J]. Scientific Reports, 2016, 6 (1): 26112.
[15]	Li D, Zeng Z, Wu J, et al. Research Progress of Effects and Mechanism of S100 Protein in the Occurrence and Development of Colorectal Cancer [J]. Med Reca, 2017, 23 (8): 1533-1538.
[16]	Du M, Wang G, Ismail TM, et al. S100P dissociates myosin IIA fi laments and focal adhesion sites to reducecell adhesionand enhance cell migration [J]. J BiolChem 2012, 287 (19): 15330-15344.
[17]	Poeter M, Radke S, Koese M. Disruption of the annexin A1/S100A11 compl-ex increases the migration and clonogenic growth by dysregulatingepithe-lial growth factor (EGF) signaling [J]. BiochimBiophysActa [J]. 2013, 1833 (7): 1700-1711.
[18]	Huang M Y, Wang H M, Chang H J, et al. Overexpression of S100B, TM4SF4, and OLFM4 Genes Is Correlated with Liver Metastasis in Taiwanese Colorectal Cancer Patients [J]. DNA and cell biology, 2012, 31 (1): 43-49.
[19]	Lines KE, Chelala C, Dmitrovic B, et al. S100P-binding protein, S100P-BP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells [J]. Am J Pathol, 2012, 180 (4): 1485-1494.
[20]	Prica F, Radon T, Cheng Y, et al. The life and works of S100P-from conception to cancer [J]. Am J Cancer Res, 2016, 6 (2): 562-576.
[21]	Wang Q, Zhang YN, Lin GL, et al. S100P, a potential novel prognosticmarker in colorectal cancer [J]. Oncol Rep, 2012, 28 (1): 303-310.
[22]	Li XY, Zhang QF, Zhang HL, et al. Expression and significance of S100P protein in colorectal carcinoma [J]. Mode Med & Health Rese, 2019, 3 (3): 82-84.
[23]	Liu J, Li X, Dong GL, et al. Insilico analysis and verification of S100 gene expression in gastric Cancen [J]. BMC Cancer, 2008, 8: 261.
[24]	Joghetaei N, Akhyari P, Ranch BH, et al. Extracellular matrix metalloproteinase inducer (CD 147) and membrance type 1-matrix metalloproteinaseare expressed on tissue macrophages in caleific aortic stenosis and induce transmigration in an artificial valvemodel [J]. J ThoracGardiovascSurg, 2011, 142 (1): 191-198.
[25]	Zhao XM, Bai ZG, Ma XM, et al. Impact of S100P expression on clinical outcomes of gastric cancer pat ients with adjuvant chemotherapy of oxaliplatin and its mechanisms [J]. Chin J Surg, 2010, 48 (13): 1004-1008.
[26]	Ge F, Wang C, Wang W, et al. S100P predicts prognosis and drugresistance in gastric cancer [J]. Int J Biol Markers, 2013, 28 (4): 387-392.
[27]	Diederichs S, Bulk E, Steffen B, et al. S100 family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer [J]. Cancer Res, 2004, 64 (16): 5564-5569.
[28]	Jia SQ, Ji JF, Su XL. Down-regulated Expression of S100P in Gastric Cancer and Its Significance [J]. Cancer prev& treat research 2011, 38 (4): 423-426.
[29]	Jia SQ, Niu ZJ, Zhang LH, et al. Identification of prognosis-relatedproteins in advanced gastric cancer by mass spectrometry-based comparative proteomics [J]. J Cancer Res ClinOncol, 2009, 135 (3): 403-411.
[30]	Zhou JF, Shen QX. Expression of CD147 and S100p in gastric cancer tissue and its clinical significance Significance of research [J]. Mode J IntegTradi Chin and West Med, 2016, 25 (9): 973-975.
[31]	Qiao XJ, Su XL, Shi YH, et al. Expressions of S100 calcium-binding protein P in gastric cancer tissue and serum of patients with gastrc cancer and their clinical significances [J]. J Jilin Universty (Med Edition), 2015, 41 (4): 830-835.
[32]	Li B, Luo LL, Lai DN. Expression and significance of S100P, CD147 and OCT4 in different stages of TNM of gastric cancer [J]. J Hebei Med, 2016, 38 (4): 492-495.
[33]	Zhan HJ, Liang H, Liu HM, et al. Prognostic analysis of intraoperative chemohyperthermic peritoneal perfusion in patients with advanced gastric cancer of different pathological types and Borrmann's classifications [J]. Chin J ClinOncol, 2020, 47 (3): 135-139.
[34]	Wang ZH, Cao L, Liang P, et al. Analysis of risk factors for lymph node groups 5 and 6 metastasis in gastric cancer [J]. J Surg Concepts Prac, 2020, 25 (3): 217-221.
[35]	Song XH, Zhang WH, Kai-Liu, et al. Prognostic impact of Borrmann classification on advanced gastric cancer: a retros-pective cohort from a single institution in western China [J]. World J SurgOncol. 2020, 18 (1): 204.
[36]	Liu JY, Jin SL, Liu BZ. Expression of CD147 and S100P in gastric cancer tissues and its clinical significance [J]. J North Sichuan Med Colle, 2017, 32 (4): 583-586.
[37]	Hou JZ, Li Y. Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics [J]. American Journal of Biomedical and Life Sciences. 2020, 8 (4): 119-125.
[38]	Bhushan B, Edwards G, Desai A, et al. Liver-Specific Deletion of Integr-in-Linked Kinase in Mice Attenuates Hepatotoxicity and Improves Liver Regeneration After Acetaminophen Overdose [J]. Gene Expr. 2016, 17 (1): 35-45.
[39]	38Shen H, Ma JL, Zhang Y, et al. Integrin-linked kinase overexpression promotes epith-elial-mesenchymal transition via nuclear factor-κB signaling in colorectal cancer cells. World J Gastroenterol. 2016, 22 (15): 3969-3977.
[40]	39Chou CC, Chuang HC, Salunke SB, et al. A novel HIF-1α-integrin-Linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells. [J]. Oncotarget, 2015, 6 (10): 8271-8285.
[41]	Lin FY, Jiang L. Current Research Advances in Relationship betweenS100P and Digestive Cancer [J]. Chin J Cell Biol 2013, 35 (5): 734-740.
[42]	Bresnick AR, Weber DJ, Zimmer DB. S100 proteins in cancer [J]. Nat Rev Cancer, 2015, 15 (2): 96-109.
[43]	Hamada S, Satoh K, Hirota M, et al. Calcium-binding protein S100P is a novel diagnostic marker of cholangiocarcinoma [J]. Cancer Sci, 2011, 102 (1): 150-156.
[44]	Zhang Q, Hu HL, Shi X et al. Construction of Shrnalentiviral vector of S100P gene and its effect on biological behavior of MGC-803 cells [J]. J Southeast Univ (Med Sci Edi), 2015, 34 (1): 65-70.

Cite This Article

Plain Text BibTeX RIS

APA Style

Hou Jianzhang, Li Yong. (2021). Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology. American Journal of Clinical and Experimental Medicine, 9(3), 55-64. https://doi.org/10.11648/j.ajcem.20210903.12

Copy | Download

ACS Style

Hou Jianzhang; Li Yong. Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology. Am. J. Clin. Exp. Med. 2021, 9(3), 55-64. doi: 10.11648/j.ajcem.20210903.12

Copy | Download

AMA Style

Hou Jianzhang, Li Yong. Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology. Am J Clin Exp Med. 2021;9(3):55-64. doi: 10.11648/j.ajcem.20210903.12

Copy | Download

@article{10.11648/j.ajcem.20210903.12,
  author = {Hou Jianzhang and Li Yong},
  title = {Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {9},
  number = {3},
  pages = {55-64},
  doi = {10.11648/j.ajcem.20210903.12},
  url = {https://doi.org/10.11648/j.ajcem.20210903.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210903.12},
  abstract = {Purpose: Discuss the diagnosis value and action mechanism of S100P for gastric cancer and the influence of S100P in tumor metastasis. Method: Collect 100 cases of gastric cancer tissues diagnosed as per histopathology by our hospital, apply immunohistochemistry method, test the positive expression condition of S100P protein, compare with 100 cases of control tissue specimens, and analyze the relationship between S100 protein expression condition in gastric cancer tissue and clinical pathology. Result: the positive rate (51.0%) of S100P in gastric cancer tissue is significantly lower than chronic atrophic gastritis with atypical hyperplasia, superficial gastritis and normal gastric mucosa (P0.05). The difference of positive rate of S100P in gastric cancer tissue with gender, age, tumor size, tumor position and Lauren typing has no statistic significance. In well differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated adenocarcinoma and adenocarcinoma anaplastic, the positive rate (80.56%) of S100P of the three groups has significant difference (χ2=13.912, P=0.001). The positive rate of S100P which doesn’t invade serosa is significantly higher than the positive rate (34.38%, χ2=19.662, P2=13.347, P=0.004), the positive rate (73.17%) of localized S100P protein is significantly higher than the positive rate (35.59%, χ2=13.669, P2=15.020, P<0.001) with lymph node metastasis. Conclusion: the positive rate of S100P protein in gastric cancer tissue is significantly lower than the para-carcinoma tissue; the lower the differentiation degree is, the deeper the invasion is; the patients who have later TNM staging and Borrmanntyping, and lymph node metastasis have lower positive rate of S100P protein, which indicates that the low expression of S100P protein participates in the occurrence, development, invasion and metastasis of gastric cancer, and is an independent dangerous factor affecting the patients’ prognosis.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology
AU  - Hou Jianzhang
AU  - Li Yong
Y1  - 2021/05/24
PY  - 2021
N1  - https://doi.org/10.11648/j.ajcem.20210903.12
DO  - 10.11648/j.ajcem.20210903.12
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 55
EP  - 64
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20210903.12
AB  - Purpose: Discuss the diagnosis value and action mechanism of S100P for gastric cancer and the influence of S100P in tumor metastasis. Method: Collect 100 cases of gastric cancer tissues diagnosed as per histopathology by our hospital, apply immunohistochemistry method, test the positive expression condition of S100P protein, compare with 100 cases of control tissue specimens, and analyze the relationship between S100 protein expression condition in gastric cancer tissue and clinical pathology. Result: the positive rate (51.0%) of S100P in gastric cancer tissue is significantly lower than chronic atrophic gastritis with atypical hyperplasia, superficial gastritis and normal gastric mucosa (P0.05). The difference of positive rate of S100P in gastric cancer tissue with gender, age, tumor size, tumor position and Lauren typing has no statistic significance. In well differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated adenocarcinoma and adenocarcinoma anaplastic, the positive rate (80.56%) of S100P of the three groups has significant difference (χ2=13.912, P=0.001). The positive rate of S100P which doesn’t invade serosa is significantly higher than the positive rate (34.38%, χ2=19.662, P2=13.347, P=0.004), the positive rate (73.17%) of localized S100P protein is significantly higher than the positive rate (35.59%, χ2=13.669, P2=15.020, P<0.001) with lymph node metastasis. Conclusion: the positive rate of S100P protein in gastric cancer tissue is significantly lower than the para-carcinoma tissue; the lower the differentiation degree is, the deeper the invasion is; the patients who have later TNM staging and Borrmanntyping, and lymph node metastasis have lower positive rate of S100P protein, which indicates that the low expression of S100P protein participates in the occurrence, development, invasion and metastasis of gastric cancer, and is an independent dangerous factor affecting the patients’ prognosis.
VL  - 9
IS  - 3
ER  -

Copy | Download

Author Information

Hou Jianzhang

Third Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, China
Li Yong

Third Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Hou Jianzhang, Li Yong. (2021). Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology. American Journal of Clinical and Experimental Medicine, 9(3), 55-64. https://doi.org/10.11648/j.ajcem.20210903.12

Copy | Download

ACS Style

Hou Jianzhang; Li Yong. Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology. Am. J. Clin. Exp. Med. 2021, 9(3), 55-64. doi: 10.11648/j.ajcem.20210903.12

Copy | Download

AMA Style

Hou Jianzhang, Li Yong. Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology. Am J Clin Exp Med. 2021;9(3):55-64. doi: 10.11648/j.ajcem.20210903.12

Copy | Download

@article{10.11648/j.ajcem.20210903.12,
  author = {Hou Jianzhang and Li Yong},
  title = {Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {9},
  number = {3},
  pages = {55-64},
  doi = {10.11648/j.ajcem.20210903.12},
  url = {https://doi.org/10.11648/j.ajcem.20210903.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210903.12},
  abstract = {Purpose: Discuss the diagnosis value and action mechanism of S100P for gastric cancer and the influence of S100P in tumor metastasis. Method: Collect 100 cases of gastric cancer tissues diagnosed as per histopathology by our hospital, apply immunohistochemistry method, test the positive expression condition of S100P protein, compare with 100 cases of control tissue specimens, and analyze the relationship between S100 protein expression condition in gastric cancer tissue and clinical pathology. Result: the positive rate (51.0%) of S100P in gastric cancer tissue is significantly lower than chronic atrophic gastritis with atypical hyperplasia, superficial gastritis and normal gastric mucosa (P0.05). The difference of positive rate of S100P in gastric cancer tissue with gender, age, tumor size, tumor position and Lauren typing has no statistic significance. In well differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated adenocarcinoma and adenocarcinoma anaplastic, the positive rate (80.56%) of S100P of the three groups has significant difference (χ2=13.912, P=0.001). The positive rate of S100P which doesn’t invade serosa is significantly higher than the positive rate (34.38%, χ2=19.662, P2=13.347, P=0.004), the positive rate (73.17%) of localized S100P protein is significantly higher than the positive rate (35.59%, χ2=13.669, P2=15.020, P<0.001) with lymph node metastasis. Conclusion: the positive rate of S100P protein in gastric cancer tissue is significantly lower than the para-carcinoma tissue; the lower the differentiation degree is, the deeper the invasion is; the patients who have later TNM staging and Borrmanntyping, and lymph node metastasis have lower positive rate of S100P protein, which indicates that the low expression of S100P protein participates in the occurrence, development, invasion and metastasis of gastric cancer, and is an independent dangerous factor affecting the patients’ prognosis.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology
AU  - Hou Jianzhang
AU  - Li Yong
Y1  - 2021/05/24
PY  - 2021
N1  - https://doi.org/10.11648/j.ajcem.20210903.12
DO  - 10.11648/j.ajcem.20210903.12
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 55
EP  - 64
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20210903.12
AB  - Purpose: Discuss the diagnosis value and action mechanism of S100P for gastric cancer and the influence of S100P in tumor metastasis. Method: Collect 100 cases of gastric cancer tissues diagnosed as per histopathology by our hospital, apply immunohistochemistry method, test the positive expression condition of S100P protein, compare with 100 cases of control tissue specimens, and analyze the relationship between S100 protein expression condition in gastric cancer tissue and clinical pathology. Result: the positive rate (51.0%) of S100P in gastric cancer tissue is significantly lower than chronic atrophic gastritis with atypical hyperplasia, superficial gastritis and normal gastric mucosa (P0.05). The difference of positive rate of S100P in gastric cancer tissue with gender, age, tumor size, tumor position and Lauren typing has no statistic significance. In well differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated adenocarcinoma and adenocarcinoma anaplastic, the positive rate (80.56%) of S100P of the three groups has significant difference (χ2=13.912, P=0.001). The positive rate of S100P which doesn’t invade serosa is significantly higher than the positive rate (34.38%, χ2=19.662, P2=13.347, P=0.004), the positive rate (73.17%) of localized S100P protein is significantly higher than the positive rate (35.59%, χ2=13.669, P2=15.020, P<0.001) with lymph node metastasis. Conclusion: the positive rate of S100P protein in gastric cancer tissue is significantly lower than the para-carcinoma tissue; the lower the differentiation degree is, the deeper the invasion is; the patients who have later TNM staging and Borrmanntyping, and lymph node metastasis have lower positive rate of S100P protein, which indicates that the low expression of S100P protein participates in the occurrence, development, invasion and metastasis of gastric cancer, and is an independent dangerous factor affecting the patients’ prognosis.
VL  - 9
IS  - 3
ER  -

Copy | Download